作为 SIV 感染天然宿主的非洲绿猴肠道丁酸盐产生菌和脂质代谢的特征。

IF 3.4 2区 医学 Q3 IMMUNOLOGY AIDS Pub Date : 2024-09-01 Epub Date: 2024-05-30 DOI:10.1097/QAD.0000000000003944
Jingjing Zhao, Xiaojun Zhou, Yefeng Qiu, Rui Jia
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引用次数: 0

摘要

目的:猿类免疫缺陷病毒(SIV)的天然宿主,如非洲绿猴(AGM),尽管终生感染SIV,但仍有能力避免获得性免疫缺陷综合症(AIDS)。其根本机制尚未完全明了。本研究旨在描述不同非人灵长类动物(NHPs)的肠道微生物组和代谢物特征,以提供对艾滋病抗药性的潜在见解:收集猕猴(CMs)、恒河猴(RMs)、SIV- AGMs(AGM_N)和SIV+ AGMs(AGM_P)的新鲜粪便,并进行元基因组测序和代谢组学分析:结果表明:与 CMs 和 RMs 相比,链球菌、螺旋体、特雷波内菌、乳杆菌和甲烷杆菌的丰度显著下降(P 结论:与 CMs 和 RMs 相比,链球菌、螺旋体、特雷波内菌、乳杆菌和甲烷杆菌的丰度显著下降(P 结论):我们的数据首次证明了不同的 SIV 感染 NHP 宿主在丁酸菌丰度和脂质代谢能力方面的不同特征。这些发现可能与这些宿主在维持肠上皮屏障完整性和调节炎症方面的不同特征有关,并为了解 AGMs 的艾滋病抗药性提供了见解。
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Characterization of the gut butyrate-producing bacteria and lipid metabolism in African green monkey as a natural host of simian immunodeficiency virus infection.

Objective: Natural hosts of simian immunodeficiency virus (SIV), such as the African green monkey (AGM), possess the ability to avoid acquired immune deficiency syndrome (AIDS) despite lifelong infection. The underlying mechanisms are not completely understood. This study aimed to characterize the gut microbiome and metabolite profiles of different nonhuman primates (NHPs) to provide potential insight into AIDS resistance.

Design and methods: Fresh feces from Cynomolgus macaques (CMs), and Rhesus macaques (RMs), SIV- AGMs (AGM_N), and SIV+ AGMs (AGM_P) were collected and used for metagenomic sequencing and metabonomic analysis.

Results: Compared with CMs and RMs, significant decreases in the abundances of Streptococcus , Alistipes , Treponema , Bacteroides , and Methanobrevibacter ( P  < 0.01), and significant increases in the abundances of Clostridium , Eubacterium , Blautia , Roseburia , Faecalibacterium , and Dialister ( P  < 0.01) were detected in AGM_N. Compared with AGM_N, a trend toward increased abundances of Streptococcus and Roseburia were found in AGM_P. The levels of metabolites involved in lipid metabolism and butanoate metabolism significantly differed among AGM_P, AGM_N and CM ( P  < 0.05).

Conclusions: Our data, for the first time, demonstrated distinguishing features in the abundances of butyrate-producing bacteria and lipid metabolism capacities between different NHP hosts of SIV infection. These findings may correlate with the different characteristics observed among these hosts in the maintenance of intestinal epithelial barrier integrity, regulation of inflammation, and provide insights into AIDS resistance in AGMs.

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来源期刊
AIDS
AIDS 医学-病毒学
CiteScore
5.90
自引率
5.30%
发文量
478
审稿时长
3 months
期刊介绍: ​​​​​​​​​​​​​​​​​Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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