María Cecilia Lira, Lorenzo Galluzzi, Claire Vanpouille-Box
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引用次数: 0
摘要
众所周知，前列腺素 E2（PGE2）可促进癌细胞增殖，同时抑制抗癌免疫，从而促进肿瘤进展。Lacher 等人和 Morotti 等人的最新数据表明，PGE2 抑制肿瘤靶向免疫反应的机制之一是下调白细胞介素 2（IL2）受体，从而抑制 T 细胞的线粒体代谢。
COX2-dependent suppression of anticancer immunity.
Prostaglandin E2 (PGE2) is well known to promote tumor progression by boosting cancer cell proliferation while inhibiting anticancer immunity. Recent data from Lacher et al. and Morotti et al. demonstrate that one of the mechanisms through which PGE2 suppresses tumor-targeting immune responses involves downregulation of interleukin 2 (IL2) receptors and consequent inhibition of mitochondrial metabolism in T cells.
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