多发性结直肠息肉患者的 APOE 基因型、二十碳五烯酸 (EPA) 补充剂和 n-3 高度不饱和脂肪酸 (HUFA) 水平：seAFOod息肉预防试验的二次分析。

IF 3 Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2024-02-01 DOI:10.1016/j.plefa.2024.102623

Ge Sun , John R. Davies , Tracey Mell , Mark Harland , Rasha M.H. Saleh , Amanda D. Race , Paul M. Loadman , Elizabeth A. Williams , Anne Marie Minihane , Mark A. Hull

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引用次数: 0

摘要

简介我们研究了seAFOod试验参与者的载脂蛋白E（APOE）基因型与n-3高度不饱和脂肪酸（HUFA）水平之间的关系：根据 584 名参与者的 APOE 基因型（基于多态性 rs429358 和 rs7412）分析了 n-3 HUFAs 和血浆 18-hydroxyeicosapentaenoic acid (HEPE) 的基线水平和治疗期间（每天 2 克二十碳五烯酸 [EPA] 或 6 个月安慰剂）的水平：治疗前，与 APOE3/3 基因型的人相比，APOE2/2 基因型的人体内 n-3 HUFAs（包括 EPA）的含量较低，而 APOE4/4 基因型的人体内 n-3 HUFAs（包括 EPA）的含量较高（APOE2/2 与 APOE4/4 基因型的比较，P < 0.01）。补充 EPA 后，按 APOE 基因型分层，n-3 HUFA 水平没有显著差异，但 APOE4 携带者的血浆 18-HEPE 水平低于没有 APOE4 等位基因的个体（P = 0.002）：结论：APOE 基因型与多发性结直肠息肉患者的 n-3 HUFA 和 18-HEPE 水平差异有关。

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APOE genotype, eicosapentaenoic acid (EPA) supplementation and n-3 highly unsaturated fatty acid (HUFA) levels in patients with multiple colorectal polyps: A secondary analysis of the seAFOod polyp prevention trial

Introduction

We examined the relationship between Apolipoprotein E (APOE) genotype and n-3 highly unsaturated fatty acid (HUFA) levels in participants of the seAFOod trial, who were undergoing colonoscopy surveillance after removal of colorectal polyps.

Methods

Baseline and on-treatment (eicosapentaenoic acid [EPA] 2 g daily or placebo for 6 months) levels of n-3 HUFAs, and plasma 18-hydroxyeicosapentaenoic acid (HEPE), were analysed according to APOE genotype (based on polymorphisms rs429358 and rs7412) in 584 participants.

Results

Before treatment, APOE2/2 individuals had lower levels, and APOE4/4 participants had higher levels, of n-3 HUFAs, including EPA, than APOE3/3 counterparts (P < 0.01 for the APOE2/2 versus APOE4/4 comparison). After EPA supplementation, n-3 HUFA levels were not significantly different when stratified by APOE genotype, although APOE4 carriers displayed lower plasma 18-HEPE levels than individuals without an APOE4 allele (P = 0.002).