{"title":"用于具有增强型近红外-II 光热疗法和超过 1500 纳米荧光发射的融合环受体的醌π桥","authors":"Wuke Cao, Xun Zhang, Xueqin Yang, Haitao Sun*, Zhongxin Chen* and Yongye Liang*, ","doi":"10.1021/acsmaterialslett.4c00759","DOIUrl":null,"url":null,"abstract":"<p >The second near-infrared window (NIR-II, 1000–3000 nm) presents an attractive platform for phototheranostics due to improved tissue penetration. However, developing efficient phototheranostic agents for this range presents a significant challenge. Herein, we report an NIR-II organic theranostic agent, CNTIC-4F, based on a fused-ring acceptor structure, which features efficient absorption extending beyond 1200 nm and fluorescence emission reaching up to 1800 nm. The incorporation of a proaromatic π-bridge, thieno[3,4-<i>b</i>]pyrazine (TP), enhances the quinoidal character of CNTIC-4F, reducing the optical bandgap and enhancing intermolecular interactions. <i>In vivo</i> fluorescence imaging of mouse vasculature with CNTIC-4F nanoparticles shows high-contrast imaging beyond 1500 nm under 1064 nm excitation. Furthermore, CNTIC-4F nanoparticles also exhibit a high photothermal conversion efficiency of 82% under 1064 nm excitation, enabling effective NIR-II imaging-guided photothermal therapy of 4T1 tumors in mice. This study illustrates the potential of quinoidal structures in developing advanced organic agents for high-contrast and deep-penetrating NIR-II phototheranostics.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":null,"pages":null},"PeriodicalIF":9.6000,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Quinoidal π-Bridges for a Fused-Ring Acceptor with Enhanced Near-Infrared-II Photothermal Therapy and Fluorescent Emission beyond 1500 nm\",\"authors\":\"Wuke Cao, Xun Zhang, Xueqin Yang, Haitao Sun*, Zhongxin Chen* and Yongye Liang*, \",\"doi\":\"10.1021/acsmaterialslett.4c00759\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The second near-infrared window (NIR-II, 1000–3000 nm) presents an attractive platform for phototheranostics due to improved tissue penetration. However, developing efficient phototheranostic agents for this range presents a significant challenge. Herein, we report an NIR-II organic theranostic agent, CNTIC-4F, based on a fused-ring acceptor structure, which features efficient absorption extending beyond 1200 nm and fluorescence emission reaching up to 1800 nm. The incorporation of a proaromatic π-bridge, thieno[3,4-<i>b</i>]pyrazine (TP), enhances the quinoidal character of CNTIC-4F, reducing the optical bandgap and enhancing intermolecular interactions. <i>In vivo</i> fluorescence imaging of mouse vasculature with CNTIC-4F nanoparticles shows high-contrast imaging beyond 1500 nm under 1064 nm excitation. Furthermore, CNTIC-4F nanoparticles also exhibit a high photothermal conversion efficiency of 82% under 1064 nm excitation, enabling effective NIR-II imaging-guided photothermal therapy of 4T1 tumors in mice. This study illustrates the potential of quinoidal structures in developing advanced organic agents for high-contrast and deep-penetrating NIR-II phototheranostics.</p>\",\"PeriodicalId\":19,\"journal\":{\"name\":\"ACS Materials Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":9.6000,\"publicationDate\":\"2024-05-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Materials Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c00759\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Materials Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c00759","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Quinoidal π-Bridges for a Fused-Ring Acceptor with Enhanced Near-Infrared-II Photothermal Therapy and Fluorescent Emission beyond 1500 nm
The second near-infrared window (NIR-II, 1000–3000 nm) presents an attractive platform for phototheranostics due to improved tissue penetration. However, developing efficient phototheranostic agents for this range presents a significant challenge. Herein, we report an NIR-II organic theranostic agent, CNTIC-4F, based on a fused-ring acceptor structure, which features efficient absorption extending beyond 1200 nm and fluorescence emission reaching up to 1800 nm. The incorporation of a proaromatic π-bridge, thieno[3,4-b]pyrazine (TP), enhances the quinoidal character of CNTIC-4F, reducing the optical bandgap and enhancing intermolecular interactions. In vivo fluorescence imaging of mouse vasculature with CNTIC-4F nanoparticles shows high-contrast imaging beyond 1500 nm under 1064 nm excitation. Furthermore, CNTIC-4F nanoparticles also exhibit a high photothermal conversion efficiency of 82% under 1064 nm excitation, enabling effective NIR-II imaging-guided photothermal therapy of 4T1 tumors in mice. This study illustrates the potential of quinoidal structures in developing advanced organic agents for high-contrast and deep-penetrating NIR-II phototheranostics.
期刊介绍:
ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.