Jit Chakraborty , Kalachand Mahali , A.M.A. Henaish , Jahangeer Ahmed , Saad M. Alshehri , Aslam Hossain , Sanjay Roy
{"title":"在温度范围为 T = 288.15 K 至 308.15 K 的 H2O + DMF、H2O + DMSO 和 H2O + ACN 的二元混合物中，探索具有重要生物意义的氨基酸 l-丝氨酸和 L-半胱氨酸的溶解度和分子间相互作用。","authors":"Jit Chakraborty , Kalachand Mahali , A.M.A. Henaish , Jahangeer Ahmed , Saad M. Alshehri , Aslam Hossain , Sanjay Roy","doi":"10.1016/j.bpc.2024.107272","DOIUrl":null,"url":null,"abstract":"<div><p>In the presented work, a study on the solubility and intermolecular interactions of <span>l</span>-serine and L-cysteine was carried out in binary mixtures of H<sub>2</sub>O + dimethylformamide (DMF), H<sub>2</sub>O + dimethylsulfoxide (DMSO), and H<sub>2</sub>O + acetonitrile (ACN) in the temperature range of <em>T</em> = 288.15 K to 308.15 K. <span>l</span>-serine exhibited the highest solubility in water, while L-cysteine was more soluble in water-DMF. The solvation process was assessed through standard Gibbs energy calculations, indicating the solvation stability order: water-ACN > water-DMSO > water-DMF for <span>l</span>-serine, and water-DMF > water-DMSO > water-ACN for L-cysteine. This study also explored the influence of these amino acids on solvent–solvent interactions, revealing changes in chemical entropies and self-association patterns within the binary solvent mixtures.</p></div>","PeriodicalId":8979,"journal":{"name":"Biophysical chemistry","volume":"311 ","pages":"Article 107272"},"PeriodicalIF":3.3000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the solubility and intermolecular interactions of biologically significant amino acids l-serine and L-cysteine in binary mixtures of H2O + DMF, H2O + DMSO and H2O + ACN in temperature range from T = 288.15 K to 308.15 K\",\"authors\":\"Jit Chakraborty , Kalachand Mahali , A.M.A. Henaish , Jahangeer Ahmed , Saad M. Alshehri , Aslam Hossain , Sanjay Roy\",\"doi\":\"10.1016/j.bpc.2024.107272\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In the presented work, a study on the solubility and intermolecular interactions of <span>l</span>-serine and L-cysteine was carried out in binary mixtures of H<sub>2</sub>O + dimethylformamide (DMF), H<sub>2</sub>O + dimethylsulfoxide (DMSO), and H<sub>2</sub>O + acetonitrile (ACN) in the temperature range of <em>T</em> = 288.15 K to 308.15 K. <span>l</span>-serine exhibited the highest solubility in water, while L-cysteine was more soluble in water-DMF. The solvation process was assessed through standard Gibbs energy calculations, indicating the solvation stability order: water-ACN > water-DMSO > water-DMF for <span>l</span>-serine, and water-DMF > water-DMSO > water-ACN for L-cysteine. This study also explored the influence of these amino acids on solvent–solvent interactions, revealing changes in chemical entropies and self-association patterns within the binary solvent mixtures.</p></div>\",\"PeriodicalId\":8979,\"journal\":{\"name\":\"Biophysical chemistry\",\"volume\":\"311 \",\"pages\":\"Article 107272\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biophysical chemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0301462224001017\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysical chemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0301462224001017","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Exploring the solubility and intermolecular interactions of biologically significant amino acids l-serine and L-cysteine in binary mixtures of H2O + DMF, H2O + DMSO and H2O + ACN in temperature range from T = 288.15 K to 308.15 K
In the presented work, a study on the solubility and intermolecular interactions of l-serine and L-cysteine was carried out in binary mixtures of H2O + dimethylformamide (DMF), H2O + dimethylsulfoxide (DMSO), and H2O + acetonitrile (ACN) in the temperature range of T = 288.15 K to 308.15 K. l-serine exhibited the highest solubility in water, while L-cysteine was more soluble in water-DMF. The solvation process was assessed through standard Gibbs energy calculations, indicating the solvation stability order: water-ACN > water-DMSO > water-DMF for l-serine, and water-DMF > water-DMSO > water-ACN for L-cysteine. This study also explored the influence of these amino acids on solvent–solvent interactions, revealing changes in chemical entropies and self-association patterns within the binary solvent mixtures.
期刊介绍：
Biophysical Chemistry publishes original work and reviews in the areas of chemistry and physics directly impacting biological phenomena. Quantitative analysis of the properties of biological macromolecules, biologically active molecules, macromolecular assemblies and cell components in terms of kinetics, thermodynamics, spatio-temporal organization, NMR and X-ray structural biology, as well as single-molecule detection represent a major focus of the journal. Theoretical and computational treatments of biomacromolecular systems, macromolecular interactions, regulatory control and systems biology are also of interest to the journal.
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