Comparative study between the effect of systemic use versus local use of tranexamic acid on blood loss and transfusion requirement in knee joint replacement.

Blood loss during total knee replacement (TKR) remains a significant concern. The purpose of this study is to compare the effect of systemic use versus local use of tranexamic acid on blood loss and transfusion requirements in total knee replacement. Tranexamic acid (TXA) is an effective hemostatic agent used for the reduction of blood loss and transfusion. However, the safety profile of TXA remains in question due to a potential increased risk of venous thrombosis.