用于检测不同组织中衰老细胞的 SenNet 建议。

IF 81.3 1区 生物学 Q1 CELL BIOLOGY Nature Reviews Molecular Cell Biology Pub Date : 2024-06-03 DOI:10.1038/s41580-024-00738-8
Vidyani Suryadevara, Adam D. Hudgins, Adarsh Rajesh, Alberto Pappalardo, Alla Karpova, Amit K. Dey, Ann Hertzel, Anthony Agudelo, Azucena Rocha, Bikem Soygur, Birgit Schilling, Chase M. Carver, Cristina Aguayo-Mazzucato, Darren J. Baker, David A. Bernlohr, Diana Jurk, Dilyana B. Mangarova, Ellen M. Quardokus, Elizabeth Ann L. Enninga, Elizabeth L. Schmidt, Feng Chen, Francesca E. Duncan, Francesco Cambuli, Gagandeep Kaur, George A. Kuchel, Gung Lee, Heike E. Daldrup-Link, Helene Martini, Hemali Phatnani, Iman M. Al-Naggar, Irfan Rahman, Jia Nie, João F. Passos, Jonathan C. Silverstein, Judith Campisi, Julia Wang, Kanako Iwasaki, Karina Barbosa, Kay Metis, Kerem Nernekli, Laura J. Niedernhofer, Li Ding, Lichao Wang, Lisa C. Adams, Liu Ruiyang, Madison L. Doolittle, Marcos G. Teneche, Marissa J. Schafer, Ming Xu, Mohammadjavad Hajipour, Mozhgan Boroumand, Nathan Basisty, Nicholas Sloan, Nikolai Slavov, Olena Kuksenko, Paul Robson, Paul T. Gomez, Periklis Vasilikos, Peter D. Adams, Priscila Carapeto, Quan Zhu, Ramalakshmi Ramasamy, Rolando Perez-Lorenzo, Rong Fan, Runze Dong, Ruth R. Montgomery, Sadiya Shaikh, Sanja Vickovic, Shanshan Yin, Shoukai Kang, Sonja Suvakov, Sundeep Khosla, Vesna D. Garovic, Vilas Menon, Yanxin Xu, Yizhe Song, Yousin Suh, Zhixun Dou, Nicola Neretti
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引用次数: 0

摘要

细胞衰老曾经被认为是一种组织培养特有的现象,但现在已经与人类、啮齿动物和其他物种的各种生物过程联系在一起,既有有益的作用,也有有害的作用。我们对衰老细胞生物学的大部分了解仍然源于组织培养研究,在这种研究中,培养物中的每个细胞都被驱动进入不可逆的细胞周期停滞状态。相比之下,在组织中,这些细胞相对罕见且难以定性,现在已经确定,完全分化的有丝分裂后细胞也可以获得衰老表型。SenNet生物标记物工作组的成立旨在为使用细胞衰老标记物鉴定和描述组织中的衰老细胞提供建议。在此,我们基于对现有文献的全面分析,提供了检测不同组织中衰老细胞的建议,这些文献报告了小鼠和人类 14 种组织中的衰老标记物。我们讨论了检测和表征细胞衰老的一些最新进展,包括分子衰老特征和形态学特征,以及循环标记物的使用。我们希望这项工作能成为衰老相关研究的资深研究人员和该领域新手的宝贵资源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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SenNet recommendations for detecting senescent cells in different tissues
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of our understanding of senescent cell biology still originates from tissue culture studies, where each cell in the culture is driven to an irreversible cell cycle arrest. By contrast, in tissues, these cells are relatively rare and difficult to characterize, and it is now established that fully differentiated, postmitotic cells can also acquire a senescence phenotype. The SenNet Biomarkers Working Group was formed to provide recommendations for the use of cellular senescence markers to identify and characterize senescent cells in tissues. Here, we provide recommendations for detecting senescent cells in different tissues based on a comprehensive analysis of existing literature reporting senescence markers in 14 tissues in mice and humans. We discuss some of the recent advances in detecting and characterizing cellular senescence, including molecular senescence signatures and morphological features, and the use of circulating markers. We aim for this work to be a valuable resource for both seasoned investigators in senescence-related studies and newcomers to the field. Senescent cells have complex and important roles in cancer and ageing, but they are quite rare and difficult to characterize in tissues in vivo. In this Expert Recommendation, the SenNet Biomarkers Working Group discusses recent advances in detecting and characterizing cellular senescence and provides recommendations for senescence markers in 14 human and mouse tissues.
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来源期刊
Nature Reviews Molecular Cell Biology
Nature Reviews Molecular Cell Biology 生物-细胞生物学
CiteScore
173.60
自引率
0.50%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.
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