Yonghui Ma, Guanming Shao, Yuwei Xie, Dongxia Yang, Kun Li, Bin Tan, Cong Wang, Peng Sun, Jingyu Cao
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引用次数: 0
摘要
白细胞介素-21（IL-21）是一种重要的抗肿瘤细胞因子，有助于 CD8+ T 细胞的增殖和分化。事实证明，它能增强各种实体瘤对免疫检查点抑制剂（ICIs）的反应。然而，它在肝细胞癌（HCC）中的作用尚未明确。本研究旨在探讨IL-21在HCC中的抗肿瘤作用及其对ICI治疗的影响。通过转录组测序分析和免疫组化验证，我们发现IL-21高表达的患者预后较好。IL-21 高表达的 HCC 有更高的 CD8+ T 细胞浸润，免疫检查点表达增加，对 ICI 治疗的反应也有所改善。总之，IL-21能促进CD8+ T细胞浸润和免疫检查点相关基因的表达，从而提高ICI治疗的疗效，改善患者的预后。
Multiomics Analysis of Interleukin-21 as a Potential Immunologic and Biomarker in Hepatocellular Carcinoma.
Interleukin-21 (IL-21) is an important antitumor cytokine that contributes to the proliferation and differentiation of CD8 + T cells. It has been proven to enhance the response to immune checkpoint inhibitors (ICIs) in various solid tumors. However, its role in hepatocellular carcinoma (HCC) has not yet been clarified. In this research, we aimed to investigate the antitumor effect of IL-21 in HCC and its effect on ICI treatment. Through transcriptome sequencing analysis and immunohistochemistry validation, we found that patients with high IL-21 expression had a better prognosis. HCCs with high expression of IL-21 had higher infiltration of CD8 + T cells, increased expression of immune checkpoints, and an improved response to ICI treatment. In conclusion, IL-21 can enhance the efficacy of ICI treatment and improve the prognosis of patients by promoting the infiltration of CD8 + T cells and the expression of immune checkpoint-related genes.
期刊介绍：
Journal of Immunotherapy features rapid publication of articles on immunomodulators, lymphokines, antibodies, cells, and cell products in cancer biology and therapy. Laboratory and preclinical studies, as well as investigative clinical reports, are presented. The journal emphasizes basic mechanisms and methods for the rapid transfer of technology from the laboratory to the clinic. JIT contains full-length articles, review articles, and short communications.
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