训练有素的免疫力在不同病理情况下发挥着多方面的作用。

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY BMB Reports Pub Date : 2024-10-01

Hyo Jin Park, Su Min Kim, Un Yung Choi, Lark Kyun Kim

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引用次数: 0

摘要

训练免疫是一种先天性免疫反应，其特点是细胞反应能力增强，表现出与适应性免疫类似的深刻记忆。这种现象涉及β-葡聚糖和卡介苗等刺激物引发的错综复杂的代谢和表观遗传重编程，从而形成先天性免疫记忆。在阐明训练免疫的背景之后，重要的是探讨其在各种病理情况下的多方面作用。在这篇综述中，我们将深入探讨训练有素的免疫在病毒感染、肿瘤发生和各种炎症性疾病的复杂环境中的具体作用，揭示其作为治疗靶点的潜力，并全面了解其更广泛的免疫学意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Multifaceted roles of trained immunity in diverse pathological contexts.

Trained immunity, an innate immune response characterized by enhanced cellular responsiveness, exhibits a profound memory akin to adaptive immunity. This phenomenon involves intricate metabolic and epigenetic reprogramming triggered by stimuli such as β-glucan and BCG, shaping innate immune memory. Following elucidation of the background on trained immunity, it is important to explore its multifaceted roles in various pathological contexts. In this review, we delve into the specific contributions of trained immunity in the intricate landscape of viral infections, tumorigenesis, and diverse inflammatory diseases, shedding light on its potential as a therapeutic target, and offering comprehensive understanding of its broader immunological implications. [BMB Reports 2024; 57(10): 431-440].

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来源期刊

BMB Reports 生物-生化与分子生物学

CiteScore

5.10

自引率

7.90%

发文量

141

审稿时长

1 months

期刊介绍： The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.