一家机构对低剂量纳曲酮(LDN)治疗慢性疼痛患者的使用情况回顾。

Joshua Pogue, Diane Johnson, Andrew Burch
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引用次数: 0

摘要

研究表明,LDN 对各种疼痛适应症都有益处。本综述介绍了威廉-米德尔顿退伍军人纪念医院(麦迪逊退伍军人医院)的慢性疼痛患者对 LDN 的使用情况和反应。这是对开具 LDN 治疗慢性疼痛的患者进行的一次回顾性、单中心、病历审查。通过 Wilcoxon Signed Rank Test 和描述性统计分析了主要结果,即通过数字评分量表(NRS)得出的主观疼痛报告的变化。共纳入 136 名参与者。基线时,患者的 NRS 平均疼痛评分为 7.1 分。在首次随访时,参与者的平均疼痛程度为 6.4(p < 0.001)。此外,17.1% 的患者疼痛较基线减轻了 30%。在随后的随访中,患者报告的 NRS 平均疼痛程度为 5.5(p < 0.0001)。研究结束时,31.6% 的患者仍在服用 LDN,平均剂量为 3.8 毫克。这项回顾性研究表明,LDN 可能是治疗某些慢性疼痛的有效方法。与基线相比,初次随访时所有患者的疼痛评分明显降低,尤其是纤维肌痛(FM)患者。
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A Utilization Review of Patients That Respond to Low-Dose Naltrexone (LDN) for Chronic Pain at a Single Institution.

Studies have demonstrated the benefits of LDN for various pain indications. This review describes the utilization of and response to LDN in patients with chronic pain within the William S. Middleton Memorial Veterans Hospital (Madison VA). This was a retrospective, single center, chart review of patients that were prescribed LDN for chronic pain. The primary outcome, change in subjective pain report via numeric rating scale (NRS), was analyzed through Wilcoxon Signed Rank Test and descriptive statistics. A total of 136 participants were included. Patients had an average pain score of 7.1 per NRS at baseline. At the initial follow up visit, participants had an average pain of 6.4 (p < 0.001). Additionally, 17.1% of patients had a greater than or equal to 30% pain reduction from baseline. At subsequent follow up, patients reported an average pain of 5.5 (p < 0.0001) per NRS. At the end of the study, 31.6% of patients were maintained on LDN at an average dose of 3.8 mg. This retrospective review demonstrated that LDN may be an effective modality for some chronic pain indications. Reported pain scores were significantly lower at initial follow up compared to baseline for the total population, and for patients with fibromyalgia (FM) specifically.

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来源期刊
CiteScore
1.60
自引率
9.10%
发文量
40
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