Dongxv Lu, Peng Jiang, Yanfu Wang, Yanying Li, Anam Naseem, Adnan Mohammed Algradi, Juan Pan, Wei Guan, Jiatong Wu, Haixue Kuang, Bingyou Yang, Yan Liu
{"title":"Fritillaria ussuriensis Maxim鳞茎中未描述的甾体生物碱及其抗炎活性。","authors":"Dongxv Lu, Peng Jiang, Yanfu Wang, Yanying Li, Anam Naseem, Adnan Mohammed Algradi, Juan Pan, Wei Guan, Jiatong Wu, Haixue Kuang, Bingyou Yang, Yan Liu","doi":"10.1016/j.phytochem.2024.114172","DOIUrl":null,"url":null,"abstract":"<div><p>In total, 16 undescribed steroidal alkaloids (<strong>1</strong>–<strong>16</strong>), along with nine known ones (<strong>17</strong>–<strong>25</strong>), were isolated from the bulbs of <em>Fritillaria ussuriensis</em> Maxim. Among the undescribed compounds mentioned, compounds <strong>1</strong>–<strong>6</strong>, <strong>8</strong> bearing an 16<em>β</em>-hydroxy substituent, as well as compounds <strong>13</strong> and <strong>14</strong> exhibited an unusual seven-membered skeleton. Their structures were established based on extensive spectroscopic analyses, including HRESIMS and NMR (1D and 2D), and comparison with the data reported in the literature. Furthermore, all the compounds were evaluated for their anti-inflammatory effect on the NO production of LPS-stimulated RAW264.7 cells. Compounds <strong>1</strong>, <strong>4</strong>, <strong>11</strong>, <strong>15</strong>, <strong>22</strong> and <strong>24</strong> could significantly inhibit NO production with IC<sub>50</sub> values below 10 μM.</p></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Undescribed steroidal alkaloids from the bulbs of Fritillaria ussuriensis Maxim and their anti-inflammatory activities\",\"authors\":\"Dongxv Lu, Peng Jiang, Yanfu Wang, Yanying Li, Anam Naseem, Adnan Mohammed Algradi, Juan Pan, Wei Guan, Jiatong Wu, Haixue Kuang, Bingyou Yang, Yan Liu\",\"doi\":\"10.1016/j.phytochem.2024.114172\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In total, 16 undescribed steroidal alkaloids (<strong>1</strong>–<strong>16</strong>), along with nine known ones (<strong>17</strong>–<strong>25</strong>), were isolated from the bulbs of <em>Fritillaria ussuriensis</em> Maxim. Among the undescribed compounds mentioned, compounds <strong>1</strong>–<strong>6</strong>, <strong>8</strong> bearing an 16<em>β</em>-hydroxy substituent, as well as compounds <strong>13</strong> and <strong>14</strong> exhibited an unusual seven-membered skeleton. Their structures were established based on extensive spectroscopic analyses, including HRESIMS and NMR (1D and 2D), and comparison with the data reported in the literature. Furthermore, all the compounds were evaluated for their anti-inflammatory effect on the NO production of LPS-stimulated RAW264.7 cells. Compounds <strong>1</strong>, <strong>4</strong>, <strong>11</strong>, <strong>15</strong>, <strong>22</strong> and <strong>24</strong> could significantly inhibit NO production with IC<sub>50</sub> values below 10 μM.</p></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942224002097\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224002097","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Undescribed steroidal alkaloids from the bulbs of Fritillaria ussuriensis Maxim and their anti-inflammatory activities
In total, 16 undescribed steroidal alkaloids (1–16), along with nine known ones (17–25), were isolated from the bulbs of Fritillaria ussuriensis Maxim. Among the undescribed compounds mentioned, compounds 1–6, 8 bearing an 16β-hydroxy substituent, as well as compounds 13 and 14 exhibited an unusual seven-membered skeleton. Their structures were established based on extensive spectroscopic analyses, including HRESIMS and NMR (1D and 2D), and comparison with the data reported in the literature. Furthermore, all the compounds were evaluated for their anti-inflammatory effect on the NO production of LPS-stimulated RAW264.7 cells. Compounds 1, 4, 11, 15, 22 and 24 could significantly inhibit NO production with IC50 values below 10 μM.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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