聚(乳酸-共聚乙醇)酸纳米粒子中的银纳米粒子封装及其对细胞内细菌的抗菌活性

IF 1.4 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Chemistry Letters Pub Date : 2024-05-31 DOI:10.1093/chemle/upae084
Ryoko Nawata, Sayo Maruyama, Wei Xu, Takuro Niidome
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引用次数: 0

摘要

我们将银纳米粒子(AgNPLs)封装到聚乳酸-聚乙二醇酸(PLGA)纳米颗粒中。封装后的银纳米板在生理环境中变得稳定,而银纳米板对浮游细菌的抗菌活性却降低了。然而,封装了 AgNPLs 的 PLGA 纳米颗粒却能被巨噬细胞内化,并显示出对细胞内细菌的抗菌活性。AgNPL负载的PLGA纳米颗粒有望用于治疗由感染巨噬细胞的细菌引起的难治性感染性疾病。
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Encapsulation of silver nanoplates into poly(lactic-co-glycolic) acid nanoparticles and the antibacterial activity against intracellular bacteria
We encapsulated silver nanoplates (AgNPLs) into poly(lactic-co-glycolic) acid (PLGA) nanoparticles. The encapsulation stabilized the AgNPLs in a physiological environment and the antibacterial activity of the AgNPLs against planktonic bacteria was reduced. However, the PLGA nanoparticles encapsulating the AgNPLs were internalized into macrophages and showed antibacterial activity against intracellular bacteria. AgNPL-loaded PLGA nanoparticles are promising for treating intractable infectious diseases caused by bacteria-infecting macrophages.
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来源期刊
Chemistry Letters
Chemistry Letters 化学-化学综合
CiteScore
3.00
自引率
6.20%
发文量
260
审稿时长
1.2 months
期刊介绍: Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry
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