2 型糖尿病患者低镁血症与白蛋白尿之间的关系。

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Clinical Endocrinology Pub Date : 2024-06-04 DOI:10.1111/cen.15094

Edibe S. Eker, Hayriye E. Ataoğlu

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引用次数: 0

摘要

目的：糖尿病肾病是全球慢性肾病的一个普遍病因。镁在胰岛素抵抗中起着关键作用，而胰岛素反过来又调节镁的水平。我们旨在研究 2 型糖尿病（T2DM）患者低镁血症与白蛋白尿之间的关系：这项回顾性单中心研究涵盖了2019年1月至2020年8月期间在我院门诊就诊的1178名18岁及以上的T2DM患者。白蛋白尿水平根据肾脏疾病结果质量倡议指南进行分类。在文献中，当研究低镁血症的临界值时，发现研究通常使用医院的正常水平作为参考点。低镁血症的定义是镁水平低于 1.6 毫克/分升，并与正常镁血症（镁水平在 1.6 至 2.4 毫克/分升之间）进行了比较。首要目标是探讨镁水平对白蛋白尿的影响，次要目标是确定低镁血症的患病率。根据年龄、性别（男性）、HbA1c和是否存在低镁血症进行了多变量逻辑回归分析：参与者的平均年龄为 58.7 ± 12.2 岁，男性占 44%。5.3%的患者存在低镁血症。高龄和女性在低镁血症患者中更为常见（p = .001）。镁水平与 HbA1c 和空腹血糖呈负相关，与肌酐水平呈正相关（r = -.117, r = -.131, r = .117, p 结论：低镁血症患者更易出现白蛋白尿。

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The relationship between hypomagnesemia and albuminuria in patients with type 2 diabetes mellitus

Objective

Diabetic nephropathy is a prevalent cause of chronic kidney disease worldwide. Magnesium plays a critical role in insulin resistance, and insulin, in turn, regulates magnesium levels. We aimed to investigate the association between hypomagnesemia and albuminuria in patients with type 2 diabetes mellitus (T2DM).

Design, Patients and Measurements

This retrospective single-centre study encompassed 1178 patients aged 18 and above with T2DM, who attended our outpatient clinic between January 2019 and August 2020. Albuminuria levels were categorised according to Kidney Disease Outcomes Quality Initiative guidelines. In the literature, when examining cut-off values for hypomagnesemia, it is observed that studies typically use hospital normal level as a reference point. Hypomagnesemia, defined as magnesium levels below 1.6 mg/dL, was compared to normomagnesemia (magnesium between 1.6 and 2.4 mg/dL). The primary objective was to explore the impact of magnesium levels on albuminuria, while the secondary objective was to determine the prevalence of hypomagnesemia. The multivariate logistic regression analyses were performed according to age, gender (male), HbA1c, and presence of hypomagnesemia.

Results

The mean age of the participants was 58.7 ± 12.2 years, with 44% being male. Hypomagnesemia was identified in 5.3% of the patients. Advanced age and female gender were more common among patients with hypomagnesemia (p = .001). Magnesium levels exhibited a negative correlation with HbA1c and fasting blood glucose, and a positive correlation with creatinine levels (r = −.117, r = −.131, r = .117, p < .001 for all three variables). Hypomagnesemia was significantly more prevalent in patients with albuminuria (15.9% vs. 4.7%, p < .001). Moreover, participants with the presence of hypomagnesemia were independently associated with a higher risk of albuminuria (odds ratio 3,64 1.76–7.52, p = .001).

Conclusion

Albuminuria is more frequently observed in patients with hypomagnesemia.

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来源期刊

Clinical Endocrinology 医学-内分泌学与代谢

CiteScore

6.40

自引率

3.10%

发文量

192

审稿时长

1 months

期刊介绍： Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.