Jarno Hakkers, Tine E. Vangsted, Arie Jan van Winkelhoff, Yvonne C. M. de Waal
{"title":"在种植体周围炎的非手术治疗阶段，全身使用阿莫西林和甲硝唑是否能避免将来的手术治疗？一项回顾性长期队列研究。","authors":"Jarno Hakkers, Tine E. Vangsted, Arie Jan van Winkelhoff, Yvonne C. M. de Waal","doi":"10.1111/jcpe.14024","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>The aim of this retrospective long-term follow-up of a 3-month RCT was to assess whether non-surgical peri-implantitis treatment with adjunctive systemic antibiotics influenced the need for additional surgical treatment.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Patients enrolled in an aftercare programme following non-surgical peri-implantitis treatment, with or without systemic amoxicillin and metronidazole, were analysed. Data had previously been collected pre-treatment (T<sub>0</sub>) and 3 months after treatment (T<sub>1</sub>) and were additionally collected during subsequent aftercare visits, until the final assessment (T<sub>2</sub>). Primary outcome was the need for additional surgical peri-implantitis therapy during the aftercare programme, analysed via Kaplan–Meier analysis and Cox regression. Secondary outcomes involved clinical parameters, assessed using parametric and non-parametric tests.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Forty-five patients (22 AB− group, 23 AB+ group) were included. The mean follow-up time between T<sub>1</sub> and T<sub>2</sub> was 35.9 months (SD = 21.0). 73.9% of the AB+ group and 50.0% of the AB− group did not receive additional surgical therapy (log-rank test, <i>p</i> = .110). The adjusted Cox regression model did not provide a significant result for antibiotics (<i>β</i> = .441, 95% CI = 0.159–1.220, <i>p</i> = .115). Univariable regression analysis highlighted the influence of baseline peri-implant pocket depth on the need for surgical treatment (<i>β</i> = 1.446, 95% CI = 1.035–2.020, <i>p</i> = .031).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Systemic amoxicillin and metronidazole administered during non-surgical peri-implantitis treatment do not seem to prevent the need for additional surgical therapy in the long term, during a structured aftercare programme.</p>\n </section>\n </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":null,"pages":null},"PeriodicalIF":5.8000,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14024","citationCount":"0","resultStr":"{\"title\":\"Do systemic amoxicillin and metronidazole during the non-surgical peri-implantitis treatment phase prevent the need for future surgical treatment? 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Primary outcome was the need for additional surgical peri-implantitis therapy during the aftercare programme, analysed via Kaplan–Meier analysis and Cox regression. Secondary outcomes involved clinical parameters, assessed using parametric and non-parametric tests.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Forty-five patients (22 AB− group, 23 AB+ group) were included. The mean follow-up time between T<sub>1</sub> and T<sub>2</sub> was 35.9 months (SD = 21.0). 73.9% of the AB+ group and 50.0% of the AB− group did not receive additional surgical therapy (log-rank test, <i>p</i> = .110). The adjusted Cox regression model did not provide a significant result for antibiotics (<i>β</i> = .441, 95% CI = 0.159–1.220, <i>p</i> = .115). 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Do systemic amoxicillin and metronidazole during the non-surgical peri-implantitis treatment phase prevent the need for future surgical treatment? A retrospective long-term cohort study
Aim
The aim of this retrospective long-term follow-up of a 3-month RCT was to assess whether non-surgical peri-implantitis treatment with adjunctive systemic antibiotics influenced the need for additional surgical treatment.
Materials and Methods
Patients enrolled in an aftercare programme following non-surgical peri-implantitis treatment, with or without systemic amoxicillin and metronidazole, were analysed. Data had previously been collected pre-treatment (T0) and 3 months after treatment (T1) and were additionally collected during subsequent aftercare visits, until the final assessment (T2). Primary outcome was the need for additional surgical peri-implantitis therapy during the aftercare programme, analysed via Kaplan–Meier analysis and Cox regression. Secondary outcomes involved clinical parameters, assessed using parametric and non-parametric tests.
Results
Forty-five patients (22 AB− group, 23 AB+ group) were included. The mean follow-up time between T1 and T2 was 35.9 months (SD = 21.0). 73.9% of the AB+ group and 50.0% of the AB− group did not receive additional surgical therapy (log-rank test, p = .110). The adjusted Cox regression model did not provide a significant result for antibiotics (β = .441, 95% CI = 0.159–1.220, p = .115). Univariable regression analysis highlighted the influence of baseline peri-implant pocket depth on the need for surgical treatment (β = 1.446, 95% CI = 1.035–2.020, p = .031).
Conclusions
Systemic amoxicillin and metronidazole administered during non-surgical peri-implantitis treatment do not seem to prevent the need for additional surgical therapy in the long term, during a structured aftercare programme.
期刊介绍：
Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology.
The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope.
The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.
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