Uzma Shamsi, Sajida Qureshi, Munira Moosaji, Iqbal Azam, Romana Idrees
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Adjusted hazard ratios (aHR) and their 95% confidence intervals (CIs) were estimated using a cox regression model to assess the prognostic factors for survival.</p><p><strong>Results: </strong>The overall proportion of late-onset CRC (>50 years of age) was 55.3% and early-onset CRC (<=50 years of age) was higher than expected (45.7%). A high level of carcinoembryonic antigen (CEA) (>5 ng/ml) was associated with poor survival compared to patients with CEA levels of ≤5 ng/ml (aHR = 1.68, 95% CI = 1.04, 2.72). Patients, who experienced recurrence, showed poorer survival (aHR = 4.27, 95% CI = 2.55, 7.14). Patients, who did not undergo surgery, showed significantly poorer survival compared to those who underwent surgery (aHR = 5.53, 95% CI = 2.35, 13.03).</p><p><strong>Conclusion: </strong>The findings suggest that monitoring CEA levels, ensuring prompt surgical treatment and follow-up care for recurrent cases can improve survival outcomes in patients with colorectal cancer.</p><p><strong>Key words: </strong>Colorectal cancer (CRC), Surgery, Recurrence, Grade, Cancer registry.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Colorectal Cancer Survival and Its Prognostic Factors in Karachi, Pakistan.\",\"authors\":\"Uzma Shamsi, Sajida Qureshi, Munira Moosaji, Iqbal Azam, Romana Idrees\",\"doi\":\"10.29271/jcpsp.2024.06.688\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine the survival rates of colorectal cancer (CRC) in the Pakistani population and determine the prognostic factors for survival among the CRC patients.</p><p><strong>Study design: </strong>Retrospective cohort study. Place and Duration of the Study: The cancer registry of the Aga Khan University Hospital, Karachi, Pakistan, from 2010 to 2016.</p><p><strong>Methodology: </strong>The abstracted data from the cancer registry was cleaned and updated regarding the vital status at the last follow-up. Survival analyses were performed using the Kaplan-Meier method. Adjusted hazard ratios (aHR) and their 95% confidence intervals (CIs) were estimated using a cox regression model to assess the prognostic factors for survival.</p><p><strong>Results: </strong>The overall proportion of late-onset CRC (>50 years of age) was 55.3% and early-onset CRC (<=50 years of age) was higher than expected (45.7%). A high level of carcinoembryonic antigen (CEA) (>5 ng/ml) was associated with poor survival compared to patients with CEA levels of ≤5 ng/ml (aHR = 1.68, 95% CI = 1.04, 2.72). Patients, who experienced recurrence, showed poorer survival (aHR = 4.27, 95% CI = 2.55, 7.14). 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引用次数: 0
摘要
研究目的确定巴基斯坦人口中结直肠癌(CRC)的存活率,并确定影响 CRC 患者存活率的预后因素:研究设计:回顾性队列研究。研究地点和时间:巴基斯坦卡拉奇阿迦汗大学医院癌症登记处,2010年至2016年:对从癌症登记处抽取的数据进行清理,并更新最后一次随访时的生命体征。采用 Kaplan-Meier 法进行生存分析。使用考克斯回归模型估算调整后危险比(aHR)及其95%置信区间(CI),以评估生存率的预后因素:与CEA水平≤5 ng/ml的患者相比,晚发CRC(年龄大于50岁)的总比例为55.3%,早发CRC(5 ng/ml)的生存率较低(aHR = 1.68, 95% CI = 1.04, 2.72)。复发患者的生存率较低(aHR = 4.27,95% CI = 2.55,7.14)。与接受手术的患者相比,未接受手术的患者生存率明显较低(aHR = 5.53,95% CI = 2.35,13.03):研究结果表明,监测 CEA 水平、确保及时手术治疗和对复发病例进行随访护理可改善结直肠癌患者的生存预后:结直肠癌(CRC) 手术 复发 分级 癌症登记处
Colorectal Cancer Survival and Its Prognostic Factors in Karachi, Pakistan.
Objective: To determine the survival rates of colorectal cancer (CRC) in the Pakistani population and determine the prognostic factors for survival among the CRC patients.
Study design: Retrospective cohort study. Place and Duration of the Study: The cancer registry of the Aga Khan University Hospital, Karachi, Pakistan, from 2010 to 2016.
Methodology: The abstracted data from the cancer registry was cleaned and updated regarding the vital status at the last follow-up. Survival analyses were performed using the Kaplan-Meier method. Adjusted hazard ratios (aHR) and their 95% confidence intervals (CIs) were estimated using a cox regression model to assess the prognostic factors for survival.
Results: The overall proportion of late-onset CRC (>50 years of age) was 55.3% and early-onset CRC (<=50 years of age) was higher than expected (45.7%). A high level of carcinoembryonic antigen (CEA) (>5 ng/ml) was associated with poor survival compared to patients with CEA levels of ≤5 ng/ml (aHR = 1.68, 95% CI = 1.04, 2.72). Patients, who experienced recurrence, showed poorer survival (aHR = 4.27, 95% CI = 2.55, 7.14). Patients, who did not undergo surgery, showed significantly poorer survival compared to those who underwent surgery (aHR = 5.53, 95% CI = 2.35, 13.03).
Conclusion: The findings suggest that monitoring CEA levels, ensuring prompt surgical treatment and follow-up care for recurrent cases can improve survival outcomes in patients with colorectal cancer.
Key words: Colorectal cancer (CRC), Surgery, Recurrence, Grade, Cancer registry.