从干细胞到调节性 T 细胞：可塑性的故事

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING Cell stem cell Pub Date : 2024-06-06 DOI:10.1016/j.stem.2024.05.002

Mehek Ningoo, Miguel Fribourg

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引用次数: 0

摘要

在本期杂志中，Yano 等人1 提出了一种从人类诱导多能干细胞（hiPSCs）中获得抑制性调节性 T（Treg）细胞的方法。这种方法有望解决目前体内外Treg细胞扩增和诱导方案中Treg细胞产量低的问题，而这正是自体Treg细胞治疗所面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From stem cells to regulatory T cells: A tale of plasticity

In this issue, Yano et al.¹ present a method to obtain suppressive regulatory T (Treg) cells from human induced pluripotent stem cells (hiPSCs). This approach has the potential to address the low Treg cell yields of current ex vivo Treg cell expansion and induction protocols, an unmet challenge for autologous Treg cell treatments.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.