{"title":"开发连续电位计酶生物传感器","authors":"Xinxin Xiao , Jens Ulstrup","doi":"10.1016/j.coelec.2024.101549","DOIUrl":null,"url":null,"abstract":"<div><p>Self-management of health and disease control using implantable biosensors is presently evolving strongly. Implantable biosensors require high selectivity and sensitivity, robust stability, temporal resolution, and device miniaturization. Electrochemical enzymatic biosensors that utilize specifically selective enzymes to convert the concentration of biomarker metabolites into electrochemical signals hold great promise to meet these criteria. As for electrochemical enzyme biosensors in continuous glucose monitoring, which have enjoyed great commercial success, amperometric biosensors have so far dominated enzymatic biosensor research and development. Potentiometric enzymatic biosensor research is, however, emerging with increasing strength, in particular due to greater promise for miniaturization. This minireview focuses on how to empower potentiometric enzymatic biosensors with high temporal resolution for continuous <em>in situ</em> monitoring of metabolites using the innovative non-equilibrium approach.</p></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"46 ","pages":"Article 101549"},"PeriodicalIF":7.9000,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451910324001108/pdfft?md5=25ba9ce1e9a0c7b84e6af1eccd2f9dc2&pid=1-s2.0-S2451910324001108-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Towards continuous potentiometric enzymatic biosensors\",\"authors\":\"Xinxin Xiao , Jens Ulstrup\",\"doi\":\"10.1016/j.coelec.2024.101549\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Self-management of health and disease control using implantable biosensors is presently evolving strongly. Implantable biosensors require high selectivity and sensitivity, robust stability, temporal resolution, and device miniaturization. Electrochemical enzymatic biosensors that utilize specifically selective enzymes to convert the concentration of biomarker metabolites into electrochemical signals hold great promise to meet these criteria. As for electrochemical enzyme biosensors in continuous glucose monitoring, which have enjoyed great commercial success, amperometric biosensors have so far dominated enzymatic biosensor research and development. Potentiometric enzymatic biosensor research is, however, emerging with increasing strength, in particular due to greater promise for miniaturization. This minireview focuses on how to empower potentiometric enzymatic biosensors with high temporal resolution for continuous <em>in situ</em> monitoring of metabolites using the innovative non-equilibrium approach.</p></div>\",\"PeriodicalId\":11028,\"journal\":{\"name\":\"Current Opinion in Electrochemistry\",\"volume\":\"46 \",\"pages\":\"Article 101549\"},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2024-06-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2451910324001108/pdfft?md5=25ba9ce1e9a0c7b84e6af1eccd2f9dc2&pid=1-s2.0-S2451910324001108-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Electrochemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2451910324001108\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Electrochemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451910324001108","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Towards continuous potentiometric enzymatic biosensors
Self-management of health and disease control using implantable biosensors is presently evolving strongly. Implantable biosensors require high selectivity and sensitivity, robust stability, temporal resolution, and device miniaturization. Electrochemical enzymatic biosensors that utilize specifically selective enzymes to convert the concentration of biomarker metabolites into electrochemical signals hold great promise to meet these criteria. As for electrochemical enzyme biosensors in continuous glucose monitoring, which have enjoyed great commercial success, amperometric biosensors have so far dominated enzymatic biosensor research and development. Potentiometric enzymatic biosensor research is, however, emerging with increasing strength, in particular due to greater promise for miniaturization. This minireview focuses on how to empower potentiometric enzymatic biosensors with high temporal resolution for continuous in situ monitoring of metabolites using the innovative non-equilibrium approach.
期刊介绍：
The development of the Current Opinion journals stemmed from the acknowledgment of the growing challenge for specialists to stay abreast of the expanding volume of information within their field. In Current Opinion in Electrochemistry, they help the reader by providing in a systematic manner:
1.The views of experts on current advances in electrochemistry in a clear and readable form.
2.Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
In the realm of electrochemistry, the subject is divided into 12 themed sections, with each section undergoing an annual review cycle:
• Bioelectrochemistry • Electrocatalysis • Electrochemical Materials and Engineering • Energy Storage: Batteries and Supercapacitors • Energy Transformation • Environmental Electrochemistry • Fundamental & Theoretical Electrochemistry • Innovative Methods in Electrochemistry • Organic & Molecular Electrochemistry • Physical & Nano-Electrochemistry • Sensors & Bio-sensors •
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