大鼠在疼痛抑制下食用高味液体

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2024-08-01 Epub Date: 2024-06-07 DOI:10.1097/FBP.0000000000000783
Rebecca M Craft
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引用次数: 0

摘要

本研究确定了食用高适口性液体是否是衡量雄性和雌性大鼠炎性疼痛和抗痛觉的可靠指标。在经过 10 天的习得期后,评估了胰腺内油与完全弗氏佐剂(CFA)对香草味 Ensure 消费量的影响,啜饮管的高度为离地面 12 厘米或 19 厘米。CFA明显降低了Ensure的消耗量,但在4-7天内完全恢复到了油处理对照组的水平;性别和吸管高度对Ensure的消耗量均无明显影响。CFA 还明显抑制了未暴露于 10 天习得期的大鼠的 Ensure 消费量,但仅限于雄性大鼠。为了测试 Ensure 消耗量作为疼痛测量指标的预测有效性,在 CFA 处理后的第二天分别对大鼠进行了载体、阿片类药物、非甾体抗炎药或大麻素的预处理。吗啡和布洛芬至少对一种性别的大鼠有明显的抑制作用,而四氢大麻酚则没有。布洛芬和四氢大麻酚都不会明显改变注射了 "无痛 "油的对照组的饮酒量,但吗啡会增加饮酒量。这些结果表明,无论以前是否接触过(训练过)饮用高适口性液体的过程,CFA 都会降低饮用量,但仅限于男性。尽管标准镇痛剂会减轻CFA抑制的饮水量,但非特异性的吞咽功能亢进效应会混淆结果的解释。因此,饮用高适口性液体并不是筛选候选镇痛药的最佳方法。
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Pain-suppressed consumption of highly palatable liquid in rats.

This study determined whether consumption of a highly palatable liquid is a reliable measure of inflammatory pain and antinociception in male and female rats. After a 10-day acquisition period, the impact of intraplantar oil vs. complete Freund adjuvant (CFA) on consumption of vanilla-flavored Ensure was assessed, with a sipper tube height 12 or 19 cm above the floor. CFA significantly decreased Ensure consumption, which completely recovered within 4-7 days to levels in oil-treated controls; neither sex nor sipper tube height significantly influenced Ensure consumption. CFA also significantly suppressed Ensure consumption in rats not exposed to the 10-day acquisition period, but only in males. To test the predictive validity of Ensure consumption as a measure of pain, separate rats were pretreated with a vehicle, an opioid, a nonsteroidal anti-inflammatory drug, or a cannabinoid the day after CFA treatment. Morphine and ibuprofen significantly attenuated CFA-suppressed drinking in at least one sex, and tetrahydrocannabinol did not. Neither ibuprofen nor tetrahydrocannabinol significantly altered drinking in oil-injected, 'pain-free' controls, but morphine increased drinking. These results demonstrate that CFA decreases consumption of a highly palatable liquid regardless of previous exposure (training) to the consumption procedure, but only in males. Although standard analgesics attenuate CFA-suppressed drinking, nonspecific hyperphagic effects can confound the interpretation of results. Thus, consumption of a highly palatable liquid is not an optimal measure for candidate analgesic screening.

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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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