抗生素耐药性突变率的温度依赖性。

IF 3.7 Q2 INFECTIOUS DISEASES JAC-Antimicrobial Resistance Pub Date : 2024-06-06 eCollection Date: 2024-06-01 DOI:10.1093/jacamr/dlae085
Timo J B Van Eldijk, Eleanor A Sheridan, Guillaume Martin, Franz J Weissing, Oscar P Kuipers, G Sander Van Doorn
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引用次数: 0

摘要

目的:环境条件会影响细菌的变异率。发烧是一种常见的感染反应,它会改变感染细菌的生长条件。在此,我们研究了温度变化(如与发烧相关的温度变化)如何影响抗生素耐药性的突变率:方法:我们使用波动试验来评估大肠杆菌在两种不同温度下的抗生素耐药性突变率:37°C(正常温度)和40°C(发烧温度)。我们对三种不同作用模式的抗生素:环丙沙星、利福平和氨苄西林进行了测量:在所有情况下,抗生素耐药性的突变率都与温度有关,但方式不同。发烧温度导致氨苄西林耐药性变异率降低,环丙沙星和利福平耐药性变异率升高:这项研究表明,抗生素耐药性的变异率会受到温度微小变化的影响,如发烧时的温度变化。这为减轻抗生素耐药性的出现开辟了一条新途径,即在治疗病人时,将抗生素的选择与是否抑制发烧的决定协调起来。因此,抗生素和退热策略的优化组合可能会成为对抗抗生素耐药性的新武器。
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Temperature dependence of the mutation rate towards antibiotic resistance.

Objectives: Environmental conditions can influence mutation rates in bacteria. Fever is a common response to infection that alters the growth conditions of infecting bacteria. Here we examine how a temperature change, such as is associated with fever, affects the mutation rate towards antibiotic resistance.

Methods: We used a fluctuation test to assess the mutation rate towards antibiotic resistance in Escherichia coli at two different temperatures: 37°C (normal temperature) and 40°C (fever temperature). We performed this measurement for three different antibiotics with different modes of action: ciprofloxacin, rifampicin and ampicillin.

Results: In all cases, the mutation rate towards antibiotic resistance turned out to be temperature dependent, but in different ways. Fever temperatures led to a reduced mutation rate towards ampicillin resistance and an elevated mutation rate towards ciprofloxacin and rifampicin resistance.

Conclusions: This study shows that the mutation rate towards antibiotic resistance is impacted by a small change in temperature, such as associated with fever. This opens a new avenue to mitigate the emergence of antibiotic resistance by coordinating the choice of an antibiotic with the decision of whether or not to suppress fever when treating a patient. Hence, optimized combinations of antibiotics and fever suppression strategies may be a new weapon in the battle against antibiotic resistance.

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来源期刊
CiteScore
5.30
自引率
0.00%
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审稿时长
16 weeks
期刊最新文献
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