胚胎胎盘素信号传导:新孵化雏鸡血浆游离氨基酸和骨骼肌能量代谢的影响。

IF 1.8 4区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Poultry Science Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI:10.2141/jpsa.2024017
Jun-Ichi Shiraishi, Naoko Shimakura, Kazuki Kimura, Ai-Saiga Egusa, Yoshiyuki Ohta
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引用次数: 0

摘要

尸胺是一种由赖氨酸脱羧酶降解赖氨酸产生的生物活性物质,因其生理作用而备受关注。对啮齿类动物的研究表明,它具有细胞生长调节剂的作用,尤其是肠道细菌产生的尸胺。然而,尸胺在胚胎期的营养和生理作用仍不清楚,特别是考虑到这一阶段肠道微生物群和消化功能尚未成熟。本研究探讨了尸胺在鸡胚胎发育过程中作为营养和代谢信号的潜在功能。实验采用体内给药法,以评估营养生物活性物质对发育中的鸡胚胎的影响。虽然在第 18 天的鸡胚胎体内给予尸毒后,新孵化雏鸡的体重或器官重量没有明显变化,但血浆中色氨酸、Nτ-甲基组氨酸和 Nπ- 甲基组氨酸的浓度下降,骨骼肌中胰岛素/类胰岛素生长因子 1 信号转导的基因表达上调。这些研究结果表明,尸胺会影响胚胎期色氨酸代谢和骨骼肌分解代谢,表明它是一种生物活性因子,有助于骨骼肌的能量代谢信号转导。
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Embryonic Cadaverine Signaling: Implications for Plasma Free Amino Acid and Skeletal Muscle Energy Metabolism in Newly Hatched Chicks.

Cadaverine is a bioactive substance derived from lysine degradation by lysine decarboxylase and has gained attention for its physiological effects. Studies in rodents have revealed its role as a cell growth regulator, particularly intestinal bacterial-produced cadaverine. However, the nutritional and physiological roles of cadaverine during the embryonic period remain unclear, especially considering the immature state of the gut microbiota and digestive functions during this stage. This study explored the potential functions of cadaverine as a nutritional and metabolic signal during chicken embryonic development. Experiments were conducted using an in ovo administration method to evaluate the effects of nutritional bioactive substances on developing chicken embryos. Although there were no observable changes in body or organ weights of newly hatched chicks following in ovo cadaverine administration to day 18 chick embryos, plasma tryptophan, Nτ-methylhistidine, and Nπ-methylhistidine concentrations decreased and the gene expression of insulin/insulin-like growth factor 1 signaling in skeletal muscle was upregulated. These findings imply that cadaverine influences tryptophan metabolism and skeletal muscle catabolism during the embryonic period, suggesting its role as a bioactive factor contributing to energy metabolism signaling in skeletal muscle.

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来源期刊
Journal of Poultry Science
Journal of Poultry Science AGRICULTURE, DAIRY & ANIMAL SCIENCE-
CiteScore
2.80
自引率
13.30%
发文量
26
审稿时长
12 months
期刊介绍: The Journal of Poultry Science will publish original reports and reviews which either make an original contribution to fundamental science or are of obvious application to the industry. Subjects which are covered include: breeding and genetics, nutrition and feeds, physiology, reproduction, immunology, behavior, environmental science, management and housing welfare, processing and products, and health in poultry. Submission of original articles to the Journal is open to all poultry researchers. The review articles are invited papers written by international outstanding researchers. Articles will be published in English, American style.
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