解码健康老龄人与年龄相关的颌下前庭诱发肌源性电位变化

IF 1.4 4区 医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY American Journal of Audiology Pub Date : 2024-09-03 Epub Date: 2024-06-06 DOI:10.1044/2024_AJA-23-00264
Karan Ramesh, Kumaran Thirunavukkarasu
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引用次数: 0

摘要

目的:本研究的主要目的是利用通过空气传导传递的 500 赫兹音爆刺激,评估年龄如何影响颌前庭诱发肌源性电位(mVEMP)参数:这项研究涉及 110 名参与者,年龄从 15 岁到 60 岁不等,分为五类,他们以前都没有与前庭系统有关的问题。研究人员通过 ER-3A 嵌体接受 125 分贝声压级的 500 赫兹音爆刺激。这些刺激以极性交替的方式一次向一只耳朵呈现。对所有年龄组的整流和未整流振幅、潜伏期(P11 和 N21)以及不对称比率进行了 Tukey 诚然显著差异检验。此外,还进行了多变量方差分析,以评估性别对研究变量的影响:研究中的 110 名参与者(220 耳)均提供了 mVEMP 反应,占研究对象的 100%。结果显示,P11 和 N21 峰的振幅和潜伏期延长时间都明显减少。有趣的是,年龄最小的受试者(第 1 组)的 P11 潜伏期也延长了,这表明该系统在 16 岁以后仍在不断成熟。此外,在 P11 潜伏期中还观察到了明显的性别差异。然而,在N1峰值潜伏期、峰-峰振幅、整流振幅和不对称比率方面没有明显的性别差异(P > .05):结论:前庭感觉毛细胞的结构会因退化而发生变化,其数量会随着年龄的增长而逐渐减少。正如 Merchant 等人(2000 年)所观察到的那样,半规管的退化速度快于内耳。从 40 岁开始出现线性退化后,感觉细胞和初级神经元会持续减少,直到 75 岁时约有 40% 的前庭感觉细胞丧失,而成熟度不足会导致峰值延长,振幅也会比正常值减小。因此,在进行诊断时必须考虑参与者的年龄,并根据与年龄相关的参考数据纳入相关的校正因子。
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Decoding Age-Linked Masseter Vestibular Evoked Myogenic Potential Changes in Healthy, Aging Individuals.

Purpose: The primary objective of this study was to assess how age influences masseter vestibular evoked myogenic potential (mVEMP) parameters by utilizing 500-Hz tone burst stimuli delivered through air conduction.

Method: The study involved 110 participants ranging from 15 to 60 years of age, grouped into five categories, all of whom had no previous issues related to their vestibular system. The participants were exposed to 500-Hz tone burst stimuli at 125 dB SPL through ER-3A inserts. These stimuli were presented to one ear at a time, with alternating polarity. A Tukey's honestly significant difference test was conducted to compare rectified and unrectified amplitude, along with latencies (P11 and N21) and the asymmetric ratio across all age groups. Additionally, a multivariate analysis of variance was performed to assess the impact of sex on the study variables.

Results: All 110 participants (220 ears) in the study provided mVEMP responses, encompassing 100% of the subjects. The results revealed a significant reduction in both amplitude and latency extension for the P11 and N21 peaks. Interestingly, P11 latency was also prolonged in the youngest participants (Group 1), suggesting ongoing maturation of the system even beyond the age of 16 years. Moreover, a significant sex difference was observed in the P11 latencies. However, there were no substantial sex differences (p > .05) in N1 peak latency, peak-to-peak amplitude, rectified amplitude, and asymmetric ratio.

Conclusions: Changes in structure occur due to degeneration, and the quantity of vestibular sensory hair cells gradually diminishes with age. The rate of decline is faster in semicircular canals compared to end organs, as observed by Merchant et al. (2000). Following a linear degeneration starting at the age of 40 years, a continuous reduction in sensory cells and primary neurons takes place until approximately 40% of vestibular sensory cells are lost by the age of 75 years and insufficient maturation can lead to prolonged peaks and reduced amplitudes compared with those that are considered normal. Therefore, it is crucial to consider the age of the participants when making diagnoses and incorporate relevant correction factors based on age-related reference data.

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来源期刊
American Journal of Audiology
American Journal of Audiology AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-OTORHINOLARYNGOLOGY
CiteScore
3.00
自引率
16.70%
发文量
163
审稿时长
>12 weeks
期刊介绍: Mission: AJA publishes peer-reviewed research and other scholarly articles pertaining to clinical audiology methods and issues, and serves as an outlet for discussion of related professional and educational issues and ideas. The journal is an international outlet for research on clinical research pertaining to screening, diagnosis, management and outcomes of hearing and balance disorders as well as the etiologies and characteristics of these disorders. The clinical orientation of the journal allows for the publication of reports on audiology as implemented nationally and internationally, including novel clinical procedures, approaches, and cases. AJA seeks to advance evidence-based practice by disseminating the results of new studies as well as providing a forum for critical reviews and meta-analyses of previously published work. Scope: The broad field of clinical audiology, including audiologic/aural rehabilitation; balance and balance disorders; cultural and linguistic diversity; detection, diagnosis, prevention, habilitation, rehabilitation, and monitoring of hearing loss; hearing aids, cochlear implants, and hearing-assistive technology; hearing disorders; lifespan perspectives on auditory function; speech perception; and tinnitus.
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