一立方毫米的人类大脑皮层,解决了

IF 21.2 1区 医学 Q1 NEUROSCIENCES Nature neuroscience Pub Date : 2024-06-07 DOI:10.1038/s41593-024-01688-2
Shari Wiseman
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引用次数: 0

摘要

Shapson-Coe、Januszewski、Berger 等人最近在《科学》(Science)杂志上报告了神经解剖学和连接组学的一个重要里程碑,他们利用电子显微镜重建了一立方毫米的人体皮层,达到了纳米级分辨率。他们分析的样本来自一名 45 岁女性的左侧颞中前回,切除该回是为了获取潜在的癫痫灶。基于机器学习的分类器识别出了149,871,669个突触(111,272,315个兴奋性突触和38,599,354个抑制性突触);其中99.4%的突触位于树突上,而轴突初段和体节上的突触分别只占0.197%和0.394%。对样本中所有有细胞核的细胞进行分析后发现,神经胶质细胞的数量是神经元的两倍,神经元的总体密度约为每平方毫米16,000个,低于之前通过光学显微镜得出的估计值。作者通过在线工具提供了他们的数据,用户可以申请成为 "校对员",纠正自动分割过程中出现的错误。这项工作为进一步深入研究人类皮层神经解剖学提供了宝贵的资源,并预示着绘制人类大脑回路精细图谱的可能性:科学 https://doi.org/10.1126/science.adk4858 (2024)
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来源期刊
Nature neuroscience
Nature neuroscience 医学-神经科学
CiteScore
38.60
自引率
1.20%
发文量
212
审稿时长
1 months
期刊介绍: Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.
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