磁性自愿成像

IF 21.2 1区 医学 Q1 NEUROSCIENCES Nature neuroscience Pub Date : 2024-06-07 DOI:10.1038/s41593-024-01687-3
Luis A. Mejia
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引用次数: 0

摘要

啮齿动物神经活动的多光子细胞成像通常需要固定头部。在这篇论文中,作者描述了一种基于磁铁的装置,该装置可实现大鼠自主、自控的头部固定,并对同一神经元群进行纵向成像,在不同试验中进行可靠的微米级配准。该装置与一个反射性锥形套管相结合,可促进发射荧光的收集。作者通过对转基因大鼠的海马神经元群反应进行成像验证了该系统,展示了数月甚至数年内数百次头固定诱导行为试验的日常表现。这种装置可以实现终生的笼内活动成像,而不存在任何机械固定头部的问题:Nat.原始参考文献:Nat.15, 4154 (2024)
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来源期刊
Nature neuroscience
Nature neuroscience 医学-神经科学
CiteScore
38.60
自引率
1.20%
发文量
212
审稿时长
1 months
期刊介绍: Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.
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