绵羊硬膜外注射利多卡因加或不加右美托咪定的临床效果

IF 1.6 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Small Ruminant Research Pub Date : 2024-05-27 DOI:10.1016/j.smallrumres.2024.107295
Mursaleen Rashid , Hakim Athar , Raja Aijaz Ahmad , Mehraj U. Din Dar , Syed Ashaq Hussain , Dil Mohamamad Makhdoomi
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引用次数: 0

摘要

该研究是一项随机、前瞻性、盲法临床试验,旨在比较绵羊硬膜外单独使用 2% 盐酸利多卡因 (L2%) 和联合使用右美托咪定 (DL2%) 的临床效果。共有 19 只成年绵羊(14 只雌羊;5 只雄羊)被分配到两种腰骶部硬膜外疗法中的一种:L2%(4 毫克/公斤-1)和 DL2%(2.5 微克/公斤-1 + 4 毫克/公斤-1)。药物组合的总用量保持不变。在治疗前、治疗后和恢复期分别测定了起效、镇痛、运动阻滞、镇静和行为。记录硬膜外麻醉和运动阻滞的持续时间。在治疗前和硬膜外麻醉后的 60 分钟内,每隔 15 分钟记录一次心率、血压、呼吸频率、直肠温度和毛细血管再充盈时间。两种疗法都能有效地进行硬膜外麻醉,而且所有研究动物都能轻松地完成麻醉。两种疗法都能提供完全镇痛,但在镇痛开始时间上没有明显差异(p = 0.35)。DL2% 的硬膜外麻醉持续时间(239.56 ± 19.48 分钟)明显长于 L2% (69.30 ± 3.03 分钟)(p < 0.0001)。使用 DL2%(251.89 ± 22.18 分钟)比单独使用 L2%(88.30 ± 2.36 分钟)明显延长了运动阻滞时间(p < 0.0001)。与单独使用 L2% 相比,DL2% 的中位镇痛评分明显更高。在 20% 的 L2% 和 33.3% 的 DL2% 中,必须进行镇痛复苏。
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Clinical effects of epidurally administered lidocaine with or without dexmedetomidine in sheep

The study was designed as a randomized, prospective, blinded, clinical trial to compare the clinical effects of epidural lidocaine hydrochloride 2% (L2%) alone and in combination with dexmedetomidine (DL2%) in sheep. A total of 19 adult sheep, 14 females & 5 males were assigned to one of the two lumbosacral epidural treatments: L2% (4 mg kg –1) and DL2% (2.5 µg kg –1 + 4 mg kg –1) in a randomized order. The total volume of the drug combination was kept constant. Onset, analgesia, motor blockade, sedation and behaviour were determined before treatment, after effect of treatment and at recovery. Duration of epidural anesthesia and motor blockade were recorded. Heart rate, blood pressure, respiratory rate, rectal temperature and capillary refill time were recorded prior to treatments and every 15 minutes following epidural anesthesia for 60 minutes. Epidural anesthesia was produced with both the treatments effectively and was easily performed in all the studied animals. Both the treatments provided complete analgesia however no significant difference (p = 0.35) was recorded in onset time to analgesia. Duration of epidural anesthesia was significantly greater (p < 0.0001) with DL2% (239.56 ± 19.48 min) than L2% (69.30 ± 3.03 min). Significant extension (p < 0.0001) of motor blockade was recorded with DL2% (251.89 ± 22.18 min) than with L2% (88.30 ± 2.36 min) alone. The median analgesic scores were significantly higher in DL2% in comparison to the L2% alone. Rescue analgesia had to be given in 20% of L2% and 33.3% of DL2%.

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来源期刊
Small Ruminant Research
Small Ruminant Research 农林科学-奶制品与动物科学
CiteScore
3.10
自引率
11.10%
发文量
210
审稿时长
12.5 weeks
期刊介绍: Small Ruminant Research publishes original, basic and applied research articles, technical notes, and review articles on research relating to goats, sheep, deer, the New World camelids llama, alpaca, vicuna and guanaco, and the Old World camels. Topics covered include nutrition, physiology, anatomy, genetics, microbiology, ethology, product technology, socio-economics, management, sustainability and environment, veterinary medicine and husbandry engineering.
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