从蒸三七中提取的三种新的达玛烷类三萜皂苷及其细胞毒性

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL Phytochemistry Letters Pub Date : 2024-06-08 DOI:10.1016/j.phytol.2024.06.001

Yi-Fei Yao , Wei Ni , Yong-Sheng Zhou , Huan Yan , Hai-Yang Liu

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摘要

从蒸三七中分离出了三种新的达玛烷型三萜皂苷，即 6′-巴豆酰-（20 S）-人参皂苷 Rg3（1）、6′-巴豆酰-（20 R）-人参皂苷 Rg3（2）和人参皂苷 A（3）。其中，3 是第一个带有 α、β-不饱和 γ-内酯基团的四氢化三萜类葡萄糖苷。研究人员评估了这三种分离物对五种人类癌细胞株（HL-60、A-549、SMMC-7721、MDA-MB-231 和 SW480）的细胞毒性。结果表明，化合物 1 对 HL-60 细胞株具有中等程度的细胞毒性，IC50 值为 23.39 μM。

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Three new dammarane-type triterpenoid saponins and their cytotoxicity from steamed Panax notoginseng

Three new dammarane-type triterpenoid saponins, namely 6′-crotonyl-(20 S)-ginsenoside Rg3 (1), 6′-crotonyl-(20 R)-ginsenoside Rg3 (2), and notoginsenolide A (3), were isolated from the steamed Panax notoginseng. Among them, 3 is the first tetranordamarane triterpenoid glucoside with an α, β-unsaturated γ-lactone group. The three isolates were evaluated for their cytotoxicities against five human cancer cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, and SW480). The results showed that compound 1 had moderate cytotoxicity against HL-60 cell line with an IC₅₀ value of 23.39 μM.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.