HPV 整合与宫颈癌：进化失败的病毒特征。

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-06-09 DOI:10.1016/j.molmed.2024.05.009

Mariano A Molina, Renske D M Steenbergen, Anna Pumpe, Angelique N Kenyon, Willem J G Melchers

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引用次数: 0

摘要

为了根除宫颈癌，全世界已经做出了无数努力，包括改进疾病筛查和人类乳头瘤病毒（HPV）疫苗接种计划。然而，宫颈癌每年仍夺去 30 多万妇女的生命。高危 HPV 基因型 16 和 18 的持续感染是导致癌症的主要原因，并可能导致 HPV 整合到宿主基因组中。中心教条认为，HPV 整合是肿瘤发生的重要步骤，但事实上，它阻碍了病毒的复制和传播。因此，HPV 导致宫颈癌可被视为进化失败的病毒特征。在此，我们概述了 HPV 整合的发生和机制，以及这一过程如何导致致癌转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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HPV integration and cervical cancer: a failed evolutionary viral trait.

Countless efforts have been made to eradicate cervical cancer worldwide, including improving disease screening and human papillomavirus (HPV) vaccination programs. Nevertheless, cervical cancer still claims the lives of more than 300 000 women every year. Persistent infections with high-risk HPV genotypes 16 and 18 are the main cause of cancer and may result in HPV integration into the host genome. The central dogma is that HPV integration is an important step in oncogenesis, but in fact, it impedes the virus from replicating and spreading. HPV causing cervical cancer can therefore be perceived as a failed evolutionary viral trait. Here we outline the occurrence and mechanisms of HPV integration and how this process results in oncogenic transformation.

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.

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