{"title":"3-acyloxymaltol/ethyl maltol 衍生物的设计、合成和抗霉菌活性。","authors":"","doi":"10.1080/10286020.2024.2355144","DOIUrl":null,"url":null,"abstract":"<div><p>Twenty 3-acyloxymaltol/ethyl maltol derivatives (<strong>7a-j</strong> and <strong>8a-j</strong>) were synthesized and evaluated <em>in vitro</em> for their anti-oomycete activity against <em>Phytophthora capsici</em>, respectively. Among all of twenty derivatives, more than half of the compounds <strong>7f</strong>, <strong>7h</strong>, <strong>8a-h</strong> and <strong>8j</strong> had anti-oomycete activity higher than the positive control zoxamide (EC<sub>50</sub> = 22.23 mg/L), and the EC<sub>50</sub> values of 18.66, 20.32, 12.80, 16.18, 10.59, 14.98, 16.80, 10.36, 15.32, 12.64, and 13.59 mg/L, respectively. Especially, compounds <strong>8c</strong> and <strong>8f</strong> exhibited the best anti-oomycete activity against <em>P. capsici</em> with EC<sub>50</sub> values of 10.59 and 10.36 mg/L, respectively. Overall, hydroxyl group of maltol/ethyl maltol is important active modification site.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design, synthesis, and anti-oomycete activity of 3-acyloxymaltol/ethyl maltol derivatives\",\"authors\":\"\",\"doi\":\"10.1080/10286020.2024.2355144\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Twenty 3-acyloxymaltol/ethyl maltol derivatives (<strong>7a-j</strong> and <strong>8a-j</strong>) were synthesized and evaluated <em>in vitro</em> for their anti-oomycete activity against <em>Phytophthora capsici</em>, respectively. Among all of twenty derivatives, more than half of the compounds <strong>7f</strong>, <strong>7h</strong>, <strong>8a-h</strong> and <strong>8j</strong> had anti-oomycete activity higher than the positive control zoxamide (EC<sub>50</sub> = 22.23 mg/L), and the EC<sub>50</sub> values of 18.66, 20.32, 12.80, 16.18, 10.59, 14.98, 16.80, 10.36, 15.32, 12.64, and 13.59 mg/L, respectively. Especially, compounds <strong>8c</strong> and <strong>8f</strong> exhibited the best anti-oomycete activity against <em>P. capsici</em> with EC<sub>50</sub> values of 10.59 and 10.36 mg/L, respectively. Overall, hydroxyl group of maltol/ethyl maltol is important active modification site.</p></div>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S102860202400078X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S102860202400078X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Design, synthesis, and anti-oomycete activity of 3-acyloxymaltol/ethyl maltol derivatives
Twenty 3-acyloxymaltol/ethyl maltol derivatives (7a-j and 8a-j) were synthesized and evaluated in vitro for their anti-oomycete activity against Phytophthora capsici, respectively. Among all of twenty derivatives, more than half of the compounds 7f, 7h, 8a-h and 8j had anti-oomycete activity higher than the positive control zoxamide (EC50 = 22.23 mg/L), and the EC50 values of 18.66, 20.32, 12.80, 16.18, 10.59, 14.98, 16.80, 10.36, 15.32, 12.64, and 13.59 mg/L, respectively. Especially, compounds 8c and 8f exhibited the best anti-oomycete activity against P. capsici with EC50 values of 10.59 and 10.36 mg/L, respectively. Overall, hydroxyl group of maltol/ethyl maltol is important active modification site.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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