结合氯化银、四环素和苯扎氯铵开发超级纳米抗菌剂。

0 MATERIALS SCIENCE, MULTIDISCIPLINARY Discover nano Pub Date : 2024-06-11 DOI:10.1186/s11671-024-04043-3
Syed Imdadul Hossain, Diellza Bajrami, Nazan Altun, Margherita Izzi, Cosima Damiana Calvano, Maria Chiara Sportelli, Luigi Gentile, Rosaria Anna Picca, Pelayo Gonzalez, Boris Mizaikoff, Nicola Cioffi
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引用次数: 0

摘要

在这项工作中,我们证明了简单的阳离子滴定法是生产 AgCl/抗生素混合抗菌材料的一种可扩展、快速、绿色和稳健的方法。我们将 AgNO3 滴定到盐酸四环素(TCH)水溶液中,从而一步生成 AgCl/TCH。此外,我们还研究了将无机源 Ag+ 离子(AgCl)、消毒剂(苄基-二甲基-十六烷基氯化铵,BAC)和分子抗生素(盐酸四环素,TCH)三者结合,一步合成三重协同作用的超级纳米抗菌剂。为了了解合成的超级纳米抗菌剂的性能,我们对传统的抗菌测试、工业生物膜检测方案和原位红外-ATR 微生物生物膜监测进行了调整。结果发现,AgCl/BAC/TCH 混合纳米抗菌剂在根除肠炎沙门氏菌和副鲍氏扁桃体杆菌及生物膜方面具有协同活性。这项研究为开发新的超高效纳米抗菌剂铺平了道路,这种抗菌剂在单一(纳米)制剂中结合了相对低量的多种活性物质,从而防止了对单一活性成分产生抗药性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Development of super nanoantimicrobials combining AgCl, tetracycline and benzalkonium chloride.

In this work, we demonstrate that a simple argentometric titration is a scalable, fast, green and robust approach for producing AgCl/antibiotic hybrid antimicrobial materials. We titrated AgNO3 into tetracycline hydrochloride (TCH) aqueous solution, thus forming AgCl/TCH in a one-step procedure. Furthermore, we investigated the one-pot synthesis of triply synergistic super-nanoantimicrobials, combining an inorganic source of Ag+ ions (AgCl), a disinfecting agent (benzyl-dimethyl-hexadecyl-ammonium chloride, BAC) and a molecular antibiotic (tetracycline hydrochloride, TCH). Conventional antimicrobial tests, industrial biofilm detection protocols, and in situ IR-ATR microbial biofilm monitoring, have been adapted to understand the performance of the synthesized super-nanoantimicrobial. The resulting hybrid AgCl/BAC/TCH nanoantimicrobials are found to be synergistically active in eradicating Salmonella enterica and Lentilactobacillus parabuchneri bacteria and biofilms. This study paves the way for the development of a new class of super-efficient nanoantimicrobials that combine relatively low amounts of multiple active species into a single (nano)formulation, thus preventing the development of antimicrobial resistance towards a single active principle.

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