tau-first认知蛋白病中 tau 的独特生物特性:纵向临床神经影像图谱的证据以及与晚发性阿尔茨海默病的比较。

IF 5 3区 医学 Q1 CLINICAL NEUROLOGY Psychiatry and Clinical Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-06-12 DOI:10.1111/pcn.13680
Hsin-I Chang, Chi-Wei Huang, Shu-Hua Huang, Shih-Wei Hsu, Kun-Ju Lin, Tsung-Ying Ho, Hsiu-Chuan Wu, Chiung-Chih Chang
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引用次数: 0

摘要

背景:目的:我们利用TCP患者的纵向认知和神经影像学数据探讨了tau的生物学特性,并将其与晚发性AD(LOAD)进行了比较:我们招募了 56 名 LOAD 患者、34 名 TCP 患者和 26 名认知功能未受损的对照组患者。所有参与者都有2至4张三维T1图像和2至6次年度认知评估的历史数据,随访时间为7年。采用Florzolotau(18F) PET测量Tau地形图。在LOAD组和TCP组中,我们构建了与认知测量共变的tau或灰质群。我们使用中介分析来探讨作为预测因子的区域tau负荷、作为中介因子的灰质分区以及作为结果的重要认知测试得分。我们使用线性混合效应模型分析了认知能力纵向下降和皮质厚度退化模式:结果:TCP 组在非执行领域出现了纵向下降。预测 TCP 组短期记忆得分的决定性因素是海马体积,而不是直接通过颞叶内侧和外侧的 tau 负荷。这些特征形成了与LOAD的概念差异:讨论:tau的生物学特性和认知影像学的纵向轨迹支持了TCP与LOAD之间的概念区别。TCP代表了一个特殊的实体,其特点是显著的短期记忆损伤、非执行领域的功能下降、较慢的灰质退行性变模式以及tau的限制性影响。
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Distinct biological property of tau in tau-first cognitive proteinopathy: Evidence by longitudinal clinical neuroimaging profiles and compared with late-onset Alzheimer disease.

Background: Tau-first cognitive proteinopathy (TCP) denotes a clinical phenotype of Alzheimer disease (AD) showing Florzolotau(18F) positron emission tomography (PET) positivity but a negative amyloid status.

Aim: We explored the biological property of tau using longitudinal cognitive and neuroimaging data in TCP and compared with late-onset AD (LOAD).

Method: We enrolled 56 patients with LOAD, 34 patients with TCP, and 26 cognitive unimpaired controls. All of the participants had historical data of 2 to 4 three-dimensional T1 images and 2 to 6 annual cognitive evaluations over a follow-up period of 7 years. Tau topography was measured using Florzolotau(18F) PET. In the LOAD and TCP groups, we constructed tau or gray matter clusters covarying with the cognitive measurements. We used mediator analysis to explore the regional tau load as predictor, gray matter partitions as mediators, and significant cognitive test scores as outcomes. Longitudinal cognitive decline and cortical thickness degeneration pattern were analyzed using a linear mixed-effects model.

Results: The TCP group had longitudinal declines in nonexecutive domains. The deterministic factor predicting the short-term memory score in TCP was the hippocampal volume and not directly via the medial and lateral temporal tau load. These features formed the conceptual differences with LOAD.

Discussion: The biological properties of tau and the longitudinal cognitive-imaging trajectory support the conceptual distinction between TCP and LOAD. TCP represents one specific entity featuring salient short-term memory impairment, declines in nonexecutive domains, a slower gray matter degenerative pattern, and a restricted impact of tau.

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来源期刊
CiteScore
7.40
自引率
4.20%
发文量
181
审稿时长
6-12 weeks
期刊介绍: PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author
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