Aiqiao Zhang, Shangren Wang, Li Liu, Zhexin Zhang, Yang Pan, Shuai Niu, Xiaoqiang Liu
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引用次数: 0
摘要
目的：雌激素受体（ER）基因在男性和女性生殖过程中发挥着关键作用。非梗阻性无精子症（NOA）和严重分泌性少精子症（SOL）是影响男性生育能力的最严重、最复杂的疾病。本荟萃分析旨在研究 PvuII（rs2234693，397T>C）、XbaI（rs9340799，351G>A）、AluI（1730G>A，rs4986938）和 RsaI（1082G>A，rs1256049）多态性与生精功能障碍之间的关系：系统检索了PubMed、Medline、Embase、Web of Science、Cochrane Library、中国科技期刊数据库、万方数据、中国知网等数据库中的文献，并对雌激素受体多态性与生精功能障碍的相关性进行了荟萃分析。根据设定的标准，共纳入10项研究进行分析：结果：ER α XbaI多态性降低了NOA的风险。ER α PvuII多态性与NOA和SOL无关。ERβAluI多态性增加了白种人患NOA的风险。ERβRsaI多态性降低了高加索男性罹患NOA和SOL的风险：结论：ER α XbaI 和 ER β RsaI 多态性与罹患 NOA 和 SOL 的风险有关。
Association of Polymorphisms in Estrogen Receptors with non-obstructive Azoospermia and Severe Secretory Oligozoospermia：a Meta-Analysis.
Purpose: Estrogen receptor (ER) genes play key roles in male and female reproduction. Non-obstructive azoospermia (NOA) and severe secretory oligozoospermia (SOL) are the most severe and complex conditions impacting male fertility. This meta-analysis aimed to study the association between PvuII ( rs2234693, 397T>C ), XbaI ( rs9340799, 351G>A ), AluI (1730G>A, rs4986938), and RsaI (1082G>A, rs1256049) polymorphisms and spermatogenic failure.
Materials and methods: The literature in PubMed, Medline, Embase, Web of Science, Cochrane Library, China Science and Technology Journal Database, WanFang data, and China National Knowledge Infrastructure databases were systematically searched, and a meta-analysis was conducted to investigate the association between polymorphism in estrogen receptors and spermatogenic failure. According to a set criterion, 10 studies were included for analyses.
Results: ER α XbaI polymorphism was a decreased risk of NOA. The ER α PvuII polymorphisms does not associate with NOA and SOL. ER β AluI polymorphism increased the risk of NOA in Caucasian population. ER β RsaI polymorphism was a decreased risk of NOA and SOL in Caucasian males.
Conclusion: The ER α XbaI and ER β RsaI polymorphisms are associated with the risk of NOA and SOL.
期刊介绍：
As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist.
Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.
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