主要唾液腺癌症术后放疗的时机。

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-06-12 DOI:10.1002/hed.27845

Flora Yan, Jeffrey C Liu, Rebecca Shulman, Thomas J Galloway, John A Ridge, Christopher M K L Yao

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引用次数: 0

摘要

背景：主要唾液腺癌症的PORT启动时间对生存的影响尚不清楚。我们旨在研究PORT的及时性对主要唾液腺癌症患者总生存期（OS）的影响：这是一项横断面分析，使用的数据来自国家癌症数据库（2004-2017年），纳入了接受手术和PORT治疗的主要涎腺癌患者：共纳入 5701 名患者（3133 名[55%]男性，4644 名[82%]白人，平均年龄为 59 ± 16 岁）。在整个队列中，PORT >6周与OS下降无关（1.00 aHR，95% CI 0.89-1.11）。在具体研究粘液表皮样癌患者时，PORT >6周与OS下降有关（1.27 aHR，95% CI 1.01-1.58）：总体而言，该分析并未证明在6周内开始PORT对唾液腺恶性肿瘤患者的生存有益。子集分析确实支持粘液表皮样癌患者在切除术后6周内开始PORT治疗。但在其他主要涎腺癌组织学中并未得到证实。

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Timing of postoperative radiation therapy for major salivary gland cancers.

Background: The impact of timing of PORT initiation for major salivary gland cancers on survival is unknown. We aim to examine the impact of PORT timeliness on overall survival (OS) of patients with major salivary gland cancers.

Methods: This was a cross-sectional analysis using data from the National Cancer Database (2004-2017) and included patients with major salivary gland cancer treated with surgery and PORT.

Results: In total, 5701 patients were included (3133 [55%] male, 4644 [82%] white, mean age 59 ± 16 years). For the overall cohort, PORT >6 weeks was not associated with decreased OS (1.00 aHR, 95% CI 0.89-1.11). When specifically examining patients with mucoepidermoid carcinoma, PORT >6 weeks was associated with a decreased OS (1.27 aHR, 95% CI 1.01-1.58).

Conclusions: Overall, this analysis did not demonstrate a survival benefit for initiating PORT within 6 weeks for patients with salivary gland malignancies. Subset analysis did support initiating PORT within 6 weeks after resection for patients with mucoepidermoid carcinomas. This was not demonstrated in other major salivary gland cancer histologies.

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.