Marine Chambaud, Anne-Marie Le Ray, Racha Hamzi, Thomas Charpentier, Nadège Blon, Dimitri Bréard, Pierre Le Pogam, Marc Litaudon, Vincent Dumontet, Nelly Bataillé-Simoneau, Thomas Guillemette, Philippe Simoneau, Andreas Schinkovitz, David Guilet, Guillaume Viault* and Pascal Richomme*,
{"title":"从钙叶菊中分离出的抑制折叠蛋白反应的黄酮。","authors":"Marine Chambaud, Anne-Marie Le Ray, Racha Hamzi, Thomas Charpentier, Nadège Blon, Dimitri Bréard, Pierre Le Pogam, Marc Litaudon, Vincent Dumontet, Nelly Bataillé-Simoneau, Thomas Guillemette, Philippe Simoneau, Andreas Schinkovitz, David Guilet, Guillaume Viault* and Pascal Richomme*, ","doi":"10.1021/acs.jnatprod.4c00328","DOIUrl":null,"url":null,"abstract":"<p >The unfolded protein response (UPR) is a key component of fungal virulence. The prenylated xanthone γ-mangostin isolated from <i>Garcinia mangostana</i> (Clusiaceae) fruit pericarp, has recently been described to inhibit this fungal adaptative pathway. Considering that <i>Calophyllum caledonicum</i> (Calophyllaceae) is known for its high prenylated xanthone content, its stem bark extract was fractionated using a bioassay-guided procedure based on the cell-based anti-UPR assay. Four previously undescribed xanthone derivatives were isolated, caledonixanthones N–Q (<b>3</b>, <b>4</b>, <b>8</b>, and <b>12</b>), among which compounds <b>3</b> and <b>8</b> showed promising anti-UPR activities with IC<sub>50</sub> values of 11.7 ± 0.9 and 7.9 ± 0.3 μM, respectively.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Xanthone Inhibitors of Unfolded Protein Response Isolated from Calophyllum caledonicum\",\"authors\":\"Marine Chambaud, Anne-Marie Le Ray, Racha Hamzi, Thomas Charpentier, Nadège Blon, Dimitri Bréard, Pierre Le Pogam, Marc Litaudon, Vincent Dumontet, Nelly Bataillé-Simoneau, Thomas Guillemette, Philippe Simoneau, Andreas Schinkovitz, David Guilet, Guillaume Viault* and Pascal Richomme*, \",\"doi\":\"10.1021/acs.jnatprod.4c00328\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The unfolded protein response (UPR) is a key component of fungal virulence. The prenylated xanthone γ-mangostin isolated from <i>Garcinia mangostana</i> (Clusiaceae) fruit pericarp, has recently been described to inhibit this fungal adaptative pathway. Considering that <i>Calophyllum caledonicum</i> (Calophyllaceae) is known for its high prenylated xanthone content, its stem bark extract was fractionated using a bioassay-guided procedure based on the cell-based anti-UPR assay. Four previously undescribed xanthone derivatives were isolated, caledonixanthones N–Q (<b>3</b>, <b>4</b>, <b>8</b>, and <b>12</b>), among which compounds <b>3</b> and <b>8</b> showed promising anti-UPR activities with IC<sub>50</sub> values of 11.7 ± 0.9 and 7.9 ± 0.3 μM, respectively.</p>\",\"PeriodicalId\":47,\"journal\":{\"name\":\"Journal of Natural Products \",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-06-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Products \",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.jnatprod.4c00328\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jnatprod.4c00328","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Xanthone Inhibitors of Unfolded Protein Response Isolated from Calophyllum caledonicum
The unfolded protein response (UPR) is a key component of fungal virulence. The prenylated xanthone γ-mangostin isolated from Garcinia mangostana (Clusiaceae) fruit pericarp, has recently been described to inhibit this fungal adaptative pathway. Considering that Calophyllum caledonicum (Calophyllaceae) is known for its high prenylated xanthone content, its stem bark extract was fractionated using a bioassay-guided procedure based on the cell-based anti-UPR assay. Four previously undescribed xanthone derivatives were isolated, caledonixanthones N–Q (3, 4, 8, and 12), among which compounds 3 and 8 showed promising anti-UPR activities with IC50 values of 11.7 ± 0.9 and 7.9 ± 0.3 μM, respectively.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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