与 D1 类多巴胺受体相比,阻断齿状回内的 D2 类多巴胺受体对尾舔试验中应激诱导的镇痛效果更大。

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI:10.1097/FBP.0000000000000782
Homayoon Golmohammadi, Diba Shirmohammadi, Sajad Mazaheri, Abbas Haghparast
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引用次数: 0

摘要

导言急性应激作为对厌恶刺激做出反应的一种保护机制,通常会通过促进多巴胺神经元的持续爆发性发射来抑制痛觉。此外,灵敏而先进的研究技术还发现了中海马多巴胺能终端,尤其是海马齿状回(DG)中的多巴胺能终端。此外,先前的研究表明,在炎性疼痛的情况下,海马齿状回内的多巴胺受体在强迫游泳应激(FSS)诱导的抗痛觉反应中起着关键作用。由于不同的疼痛状态可触发不同的机制和递质系统,本实验旨在研究海马DG内的多巴胺能受体在急性热痛中是否具有相同的作用:方法:97只成年雄性白化Wistar大鼠接受立体定向手术,在DG上方1毫米处单侧植入不锈钢导管。在暴露于FSS前5-10分钟向DG微量注射不同剂量的D1-和D2-样多巴胺受体拮抗剂SCH23390或舒必利,暴露于FSS后5分钟,在设定的时间间隔内进行尾搔试验,评估应激对痛觉反应的影响:结果表明,暴露于FSS可显著提高急性痛觉阈值,而在DG内给予SCH23390和舒必利可降低FSS在尾叩试验中的抗痛觉效应:此外,在急性疼痛模型中,DG内的D2样多巴胺受体似乎在FSS诱导的镇痛中起着更重要的作用。
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D2-like dopamine receptors blockade within the dentate gyrus shows a greater effect on stress-induced analgesia in the tail-flick test compared to D1-like dopamine receptors.

Introduction: Acute stress, as a protective mechanism to respond to an aversive stimulus, can often be accompanied by suppressing pain perception via promoting consistent burst firing of dopamine neurons. Besides, sensitive and advanced research techniques led to the recognition of the mesohippocampal dopaminergic terminals, particularly in the hippocampal dentate gyrus (DG). Moreover, previous studies have shown that dopamine receptors within the hippocampal DG play a critical role in induced antinociceptive responses by forced swim stress (FSS) in the presence of inflammatory pain. Since different pain states can trigger various mechanisms and transmitter systems, the present experiments aimed to investigate whether dopaminergic receptors within the DG have the same role in the presence of acute thermal pain.

Methods: Ninety-seven adult male albino Wistar rats underwent stereotaxic surgery, and a stainless steel guide cannula was unilaterally implanted 1 mm above the DG. Different doses of SCH23390 or sulpiride as D1- and D2-like dopamine receptor antagonists were microinjected into the DG 5-10 min before exposure to FSS, and 5 min after FSS exposure, the tail-flick test evaluated the effect of stress on the nociceptive response at the time-set intervals.

Results: The results demonstrated that exposure to FSS could significantly increase the acute pain perception threshold, while intra-DG administration of SCH23390 and sulpiride reduced the antinociceptive effect of FSS in the tail-flick test.

Discussion: Additionally, it seems the D2-like dopamine receptor within the DG plays a more prominent role in FSS-induced analgesia in the acute pain model.

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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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