Pietro Manuel Ferraro, Yukun Li, Raji Balasubramanian, Gary C Curhan, Eric N Taylor
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引用次数: 0
摘要
背景:有关肾结石患者代谢组学特征的信息十分有限。为了研究血浆代谢组学特征与成人发生无症状肾结石风险之间的独立关联,我们在两个大型队列中开展了前瞻性巢式病例对照研究:我们对1758名参与者进行了血浆代谢组学研究,其中包括879名结石形成者(346名来自健康专业人员随访队列[HPFS],533名来自护士健康研究[NHS] II队列)和879名非结石形成者(346名来自HPFS,533名来自NHS II),这些参与者的年龄、种族、采血时间、空腹状态以及(NHS II)绝经状态和绝经前月经周期的黄体日均匹配。条件逻辑回归模型用于估算肾结石的几率,并对体重指数(BMI)、高血压、糖尿病、噻嗪类药物的使用以及钾、动物蛋白、草酸盐、膳食钙和补充钙、咖啡因和酒精的摄入量进行了调整。在带有套索惩罚的条件逻辑回归模型中,对每个队列进行了基于血浆代谢物的评分。对在 HPFS("KMS_HPFS")和 NHS II("KMS_NHS")中得出的分数与其他队列中肾结石风险的关联性进行了测试:结果:在预设的全代谢组统计显著性水平上,多种单个代谢物与肾结石的形成有关。我们在 HPFS 和 NHS II 中发现了三种与肾结石相关的代谢物:β-隐黄素、鞘磷脂(d18:2/24:1, d18:1/24:2)和鞘磷脂(d18:2/24:2)。在 NHS II 队列中,标准化 KMS_HPFS 的结石 OR 值为 1.23(95% CI 1.05,1.44)。标准化 KMS_NHS 与预期方向一致,但在 HPFS 中未达到统计学意义(OR 1.16,95% CI 0.97,1.39):在两个队列中发现的与肾结石状态相关的特定代谢物以及血浆代谢组特征为鉴定结石形成者的特征提供了一种新方法。
期刊介绍:
The Journal of the American Society of Nephrology (JASN) stands as the preeminent kidney journal globally, offering an exceptional synthesis of cutting-edge basic research, clinical epidemiology, meta-analysis, and relevant editorial content. Representing a comprehensive resource, JASN encompasses clinical research, editorials distilling key findings, perspectives, and timely reviews.
Editorials are skillfully crafted to elucidate the essential insights of the parent article, while JASN actively encourages the submission of Letters to the Editor discussing recently published articles. The reviews featured in JASN are consistently erudite and comprehensive, providing thorough coverage of respective fields. Since its inception in July 1990, JASN has been a monthly publication.
JASN publishes original research reports and editorial content across a spectrum of basic and clinical science relevant to the broad discipline of nephrology. Topics covered include renal cell biology, developmental biology of the kidney, genetics of kidney disease, cell and transport physiology, hemodynamics and vascular regulation, mechanisms of blood pressure regulation, renal immunology, kidney pathology, pathophysiology of kidney diseases, nephrolithiasis, clinical nephrology (including dialysis and transplantation), and hypertension. Furthermore, articles addressing healthcare policy and care delivery issues relevant to nephrology are warmly welcomed.