硫化氢及其供体在心脏代谢疾病中的药理作用。

IF 19.3 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological Reviews Pub Date : 2024-08-15 DOI:10.1124/pharmrev.123.000928
Hai-Jian Sun, Qing-Bo Lu, Xue-Xue Zhu, Zhang-Rong Ni, Jia-Bao Su, Xiao Fu, Guo Chen, Guan-Li Zheng, Xiao-Wei Nie, Jin-Song Bian
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引用次数: 0

摘要

心脏代谢疾病(CMDs)是导致全球死亡的主要因素,因此亟需新型治疗干预措施。硫化氢(H2S)作为一种重要的气体递质,在哺乳动物的心脏代谢系统中具有各种生理、病理生理学和药理学影响,因而备受关注。除了在减轻氧化应激和炎症反应方面的作用外,蓬勃发展的研究还强调了 H2S 通过过硫化作用调节蛋白质的重要性,这是一种众所周知的与慢性阻塞性肺疾病发病机制密切相关的修饰。值得注意的是,包括多组学、肠道微生物菌群分析、类器官和单细胞测序技术在内的先进方法因其能够为生物医学研究提供全面的见解而日益受到重视。这些新兴方法有望描述 H2S 在健康和疾病中的药理作用。我们将批判性地评估当前的文献,以阐明 H2S 在疾病中的作用,同时还将划定它们为基于 H2S 的 CMD 药物疗法带来的机遇和挑战。意义声明 这篇综合综述涵盖了 CMDs 中 H2S 生物学和药理学的最新进展。内源性 H2S 及其供体通过调节多种蛋白质和信号通路,为 CMDs 的治疗带来了巨大希望。新技术的出现将大大推动 H2S 的药理学研究和临床转化。
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Pharmacology of Hydrogen Sulfide and Its Donors in Cardiometabolic Diseases.

Cardiometabolic diseases (CMDs) are major contributors to global mortality, emphasizing the critical need for novel therapeutic interventions. Hydrogen sulfide (H2S) has garnered enormous attention as a significant gasotransmitter with various physiological, pathophysiological, and pharmacological impacts within mammalian cardiometabolic systems. In addition to its roles in attenuating oxidative stress and inflammatory response, burgeoning research emphasizes the significance of H2S in regulating proteins via persulfidation, a well known modification intricately associated with the pathogenesis of CMDs. This review seeks to investigate recent updates on the physiological actions of endogenous H2S and the pharmacological roles of various H2S donors in addressing diverse aspects of CMDs across cellular, animal, and clinical studies. Of note, advanced methodologies, including multiomics, intestinal microflora analysis, organoid, and single-cell sequencing techniques, are gaining traction due to their ability to offer comprehensive insights into biomedical research. These emerging approaches hold promise in characterizing the pharmacological roles of H2S in health and diseases. We will critically assess the current literature to clarify the roles of H2S in diseases while also delineating the opportunities and challenges they present in H2S-based pharmacotherapy for CMDs. SIGNIFICANCE STATEMENT: This comprehensive review covers recent developments in H2S biology and pharmacology in cardiometabolic diseases CMDs. Endogenous H2S and its donors show great promise for the management of CMDs by regulating numerous proteins and signaling pathways. The emergence of new technologies will considerably advance the pharmacological research and clinical translation of H2S.

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来源期刊
Pharmacological Reviews
Pharmacological Reviews 医学-药学
CiteScore
34.70
自引率
0.50%
发文量
40
期刊介绍: Pharmacological Reviews is a highly popular and well-received journal that has a long and rich history of success. It was first published in 1949 and is currently published bimonthly online by the American Society for Pharmacology and Experimental Therapeutics. The journal is indexed or abstracted by various databases, including Biological Abstracts, BIOSIS Previews Database, Biosciences Information Service, Current Contents/Life Sciences, EMBASE/Excerpta Medica, Index Medicus, Index to Scientific Reviews, Medical Documentation Service, Reference Update, Research Alerts, Science Citation Index, and SciSearch. Pharmacological Reviews offers comprehensive reviews of new pharmacological fields and is able to stay up-to-date with published content. Overall, it is highly regarded by scholars.
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