弓形虫引起的慢性视网膜坏死

IF 2.6 4区医学 Q2 OPHTHALMOLOGY Ocular Immunology and Inflammation Pub Date : 2025-02-01 Epub Date: 2024-06-12 DOI:10.1080/09273948.2024.2362876

Alessandro Marchese, Gaia L'Abbate, Francesco Bandello, Elisabetta Miserocchi

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引用次数: 0

摘要

简介慢性视网膜坏死包括严重的闭塞性视网膜血管炎、颗粒性视网膜炎和玻璃体炎。在免疫功能障碍、巨细胞病毒（CMV）葡萄膜炎和人类免疫缺陷病毒（HIV）血清学检测阴性的患者中也可观察到这种表型：方法：病例系列：结果：我们介绍了两例病例：一名是 85 岁的女性，另一名是 76 岁的男性，他们都表现出不寻常的闭塞性泛视网膜血管病变，并伴有长期的坏死性视网膜炎和玻璃体炎。这两个病例的前房穿刺和实时聚合酶链反应（PCR）检测结果均为疱疹病毒阴性，弓形虫阳性。这些结果与弓形虫引起的慢性视网膜坏死一致：结论：对于出现慢性视网膜坏死的老年患者或免疫功能不全的患者，在鉴别诊断时应考虑弓形虫。

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Chronic Retinal Necrosis Associated with Toxoplasma Gondii.

Introduction: Chronic retinal necrosis encompasses severe occlusive retinal vasculitis, granular retinitis, and vitritis. This phenotype has been observed in patients with limited immune dysfunction, cytomegalovirus (CMV) uveitis, and negative serology for human immunodeficiency virus (HIV).

Methods: Case series.

Results: We present two cases: an 85-year-old female and a 76-year-old male, both displaying unusual occlusive panretinal vasculopathy associated with long-standing necrotizing retinitis and vitritis. Anterior chamber taps with real-time polymerase chain reaction (PCR) were negative for herpesviruses and positive for Toxoplasma gondii in both cases. These findings are consistent with chronic retinal necrosis associated with toxoplasma gondii.

Conclusions: In elderly patients or those with limited immune dysfunction who present with chronic retinal necrosis, Toxoplasma gondii should be considered in the differential diagnosis.

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.