高脂肪喂养与慢性心理压力相结合的代谢反应

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM Endocrinology, Diabetes and Metabolism Pub Date : 2024-06-12 DOI:10.1002/edm2.487

Marzieh Nemati, Fatemeh Rostamkhani, Roxana Karbaschi, Homeira Zardooz

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引用次数: 0

摘要

导言高脂饮食（HFD）摄入和日常心理应激是现代生活方式中常见的环境因素，对代谢紊乱（如糖稳态受损）起着重要作用。本研究旨在探讨高脂饮食（HFD）和心理应激联合作用对雄性大鼠慢性心理应激代谢反应的影响：方法：将雄性 Wistar 大鼠分为高脂饮食组和正常饮食组（ND），再分为应激亚组和非应激亚组。两种饮食均连续使用 5 周，并连续 7 天诱导心理应激。然后采集血样测量葡萄糖、胰岛素、游离脂肪酸、瘦素和皮质酮的浓度。随后，评估葡萄糖刺激胰腺离体胰岛释放胰岛素的情况：结果：HFD 没有明显改变空腹血浆葡萄糖、胰岛素和皮质酮的水平，但增加了血浆瘦素（7.05 ± 0.33）和 FFA（p 结论：HFD 应被视为胰岛素的一种刺激剂：高频分解代谢应被视为慢性心理压力导致代谢损伤的强化因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metabolic Responses to High-Fat Feeding and Chronic Psychological Stress Combination

Introduction

High-fat diet (HFD) consumption and being exposed to daily psychological stress, common environmental factors in modern lifestyle, play an important role on metabolic disorders such as glucose homeostasis impairment. The aim of this study was to investigate the effects of high-fat diet (HFD) and psychological stress combination on metabolic response to chronic psychological stress in male rats.

Method

Male Wistar rats were divided into HFD, and normal diet (ND) groups and then into stress and nonstress subgroups. The diets were applied for 5 weeks, and psychological stress was induced for 7 consecutive days. Then, blood samples were taken to measure glucose, insulin, free fatty acids (FFA), and leptin and corticosterone concentrations. Subsequently, glucose-stimulated insulin release from pancreatic isolated islets was assessed.

Results

HFD did not significantly change fasting plasma glucose, insulin and corticosterone levels, whereas increased plasma leptin (7.05 ± 0.33) and FFA (p < 0.01) levels and impaired glucose tolerance. Additionally, HFD and stress combination induced more profound glucose intolerance associated with increased plasma corticosterone (p < 0.01) and leptin (8.63 ± 0.38) levels. However, insulin secretion from isolated islets did not change in the presence of high-fat diet and/or stress.