[慢性肾病的非药物预防]。

Revue medicale de Liege Pub Date : 2024-06-01
Guillaume Merckx, Mélanie Somja, Gwendoline Makalou, François Jouret
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引用次数: 0

摘要

预防慢性肾脏病(CKD)是一项重要的公共卫生目标。慢性肾脏病会导致严重的心血管疾病发病率和死亡率,对生活质量造成负面影响,并对社会产生重大影响。有几种药物可以有效预防和遏制 CKD,包括肾素/血管紧张素/醛固酮系统阻断剂和 SGLT2 共转运体抑制剂。目前正在进行临床试验的新分子主要侧重于肾脏保护,如非类固醇矿皮质激素受体拮抗剂和 GPL-1 受体激动剂。除了这些药物之外,预防慢性肾脏病还有赖于对卫生饮食措施的非药物优化,包括避免吸烟、体育锻炼和饮食习惯。本文旨在详细介绍这种预防和减缓慢性肾脏病的非药物方法。
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[Non-pharmacological prevention of chronic kidney disease].

Preventing chronic kidney disease (CKD) is a major public health objective. CKD leads to significant cardiovascular morbidity and mortality, with a negative impact on quality of life and significant societal repercussions. Several drugs are effective in preventing and curbing CKD, including blockers of the renin/angiotensin/aldosterone system and inhibitors of the SGLT2 co-transporter. New molecules are currently in clinical trials focusing on the nephro-protection, such as non-steroidal mineralocorticoid receptor antagonists and GPL-1 receptor agonists. In addition to this drug arsenal, CKD prevention also relies on non-pharmacological optimization of hygienic-dietary measures, including smoking avoidance, physical activity and dietetics. The aim of this article is to detail this non-medicinal approach to the prevention and slow down of CKD.

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