Isabel Martin del Campo-Rota , Oscar Mario Delgado-Casillas , Antonio Ibarra
{"title":"妊娠糖尿病诱发的认知障碍:氧化应激作为诱导机制的意义","authors":"Isabel Martin del Campo-Rota , Oscar Mario Delgado-Casillas , Antonio Ibarra","doi":"10.1016/j.arcmed.2024.103016","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Cognitive impairment is defined as a neurological condition that alters multiple cerebral functions such as reasoning, memory, concentration, and association, among others. It has found to be widely correlated with several factors such as oxidative stress. The latter could be induced by numerous pathological conditions characterized by increased levels of free radicals and decreased levels of antioxidants. Pregnancy is a period when women undergo a physiological state of oxidative stress due to hormonal changes and increased oxygen requirements to maintain pregnancy. However, when oxidative stress exceeds antioxidant capacity, this leads to cellular damage that promotes a diabetogenic state. Recent studies suggest a possible association between gestational diabetes and cognitive impairment, but the underlying mechanisms remain unclear.</p></div><div><h3>Aims</h3><p>We aim to explore the pathophysiological relationship between cognitive impairment and oxidative stress, focusing on the possible involvement of oxidative stress as the inducing mechanism.</p></div><div><h3>Methods</h3><p>We performed a comprehensive literature review through PubMed and Google Scholar. Our keywords were “neuroinflammation”, “cognitive impairment”, “gestational diabetes”, “oxidative stress”, “antioxidants”, and “free radicals”.</p></div><div><h3>Results</h3><p>From the initial 400 records identified, a total of 78 studies were analyzed and included in our study.</p></div><div><h3>Conclusion</h3><p>Oxidative stress plays a fundamental role in the development of cognitive impairment. Understanding this correlation is essential to the development of targeted medical interventions and, ultimately, promote research and prevention that will benefit the mother-child binomial in the short and long term.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 5","pages":"Article 103016"},"PeriodicalIF":4.7000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cognitive Impairment Induced by Gestational Diabetes: Implications of Oxidative Stress as an Inducing Mechanism\",\"authors\":\"Isabel Martin del Campo-Rota , Oscar Mario Delgado-Casillas , Antonio Ibarra\",\"doi\":\"10.1016/j.arcmed.2024.103016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Cognitive impairment is defined as a neurological condition that alters multiple cerebral functions such as reasoning, memory, concentration, and association, among others. It has found to be widely correlated with several factors such as oxidative stress. The latter could be induced by numerous pathological conditions characterized by increased levels of free radicals and decreased levels of antioxidants. Pregnancy is a period when women undergo a physiological state of oxidative stress due to hormonal changes and increased oxygen requirements to maintain pregnancy. However, when oxidative stress exceeds antioxidant capacity, this leads to cellular damage that promotes a diabetogenic state. Recent studies suggest a possible association between gestational diabetes and cognitive impairment, but the underlying mechanisms remain unclear.</p></div><div><h3>Aims</h3><p>We aim to explore the pathophysiological relationship between cognitive impairment and oxidative stress, focusing on the possible involvement of oxidative stress as the inducing mechanism.</p></div><div><h3>Methods</h3><p>We performed a comprehensive literature review through PubMed and Google Scholar. Our keywords were “neuroinflammation”, “cognitive impairment”, “gestational diabetes”, “oxidative stress”, “antioxidants”, and “free radicals”.</p></div><div><h3>Results</h3><p>From the initial 400 records identified, a total of 78 studies were analyzed and included in our study.</p></div><div><h3>Conclusion</h3><p>Oxidative stress plays a fundamental role in the development of cognitive impairment. Understanding this correlation is essential to the development of targeted medical interventions and, ultimately, promote research and prevention that will benefit the mother-child binomial in the short and long term.</p></div>\",\"PeriodicalId\":8318,\"journal\":{\"name\":\"Archives of Medical Research\",\"volume\":\"55 5\",\"pages\":\"Article 103016\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Medical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0188440924000687\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Medical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0188440924000687","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Cognitive Impairment Induced by Gestational Diabetes: Implications of Oxidative Stress as an Inducing Mechanism
Background
Cognitive impairment is defined as a neurological condition that alters multiple cerebral functions such as reasoning, memory, concentration, and association, among others. It has found to be widely correlated with several factors such as oxidative stress. The latter could be induced by numerous pathological conditions characterized by increased levels of free radicals and decreased levels of antioxidants. Pregnancy is a period when women undergo a physiological state of oxidative stress due to hormonal changes and increased oxygen requirements to maintain pregnancy. However, when oxidative stress exceeds antioxidant capacity, this leads to cellular damage that promotes a diabetogenic state. Recent studies suggest a possible association between gestational diabetes and cognitive impairment, but the underlying mechanisms remain unclear.
Aims
We aim to explore the pathophysiological relationship between cognitive impairment and oxidative stress, focusing on the possible involvement of oxidative stress as the inducing mechanism.
Methods
We performed a comprehensive literature review through PubMed and Google Scholar. Our keywords were “neuroinflammation”, “cognitive impairment”, “gestational diabetes”, “oxidative stress”, “antioxidants”, and “free radicals”.
Results
From the initial 400 records identified, a total of 78 studies were analyzed and included in our study.
Conclusion
Oxidative stress plays a fundamental role in the development of cognitive impairment. Understanding this correlation is essential to the development of targeted medical interventions and, ultimately, promote research and prevention that will benefit the mother-child binomial in the short and long term.
期刊介绍:
Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.