妊娠糖尿病诱发的认知障碍:氧化应激作为诱导机制的意义

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Archives of Medical Research Pub Date : 2024-06-12 DOI:10.1016/j.arcmed.2024.103016
Isabel Martin del Campo-Rota , Oscar Mario Delgado-Casillas , Antonio Ibarra
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引用次数: 0

摘要

背景认知障碍被定义为改变推理、记忆、注意力和联想等多种大脑功能的神经系统疾病。研究发现,认知障碍与氧化应激等多种因素密切相关。氧化应激可由多种病理情况诱发,其特点是自由基水平升高和抗氧化剂水平降低。由于荷尔蒙变化和维持妊娠所需的氧气增加,妇女在怀孕期间会出现氧化应激的生理状态。然而,当氧化应激超过抗氧化能力时,就会导致细胞损伤,从而引发糖尿病。最近的研究表明,妊娠期糖尿病与认知功能障碍之间可能存在关联,但其潜在机制仍不清楚。我们的关键词是 "神经炎症"、"认知障碍"、"妊娠糖尿病"、"氧化应激"、"抗氧化剂 "和 "自由基"。结果从最初确定的 400 条记录中,共分析了 78 项研究并将其纳入我们的研究。了解这种相关性对于制定有针对性的医疗干预措施至关重要,并最终促进研究和预防工作,使母子二人在短期和长期内受益。
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Cognitive Impairment Induced by Gestational Diabetes: Implications of Oxidative Stress as an Inducing Mechanism

Background

Cognitive impairment is defined as a neurological condition that alters multiple cerebral functions such as reasoning, memory, concentration, and association, among others. It has found to be widely correlated with several factors such as oxidative stress. The latter could be induced by numerous pathological conditions characterized by increased levels of free radicals and decreased levels of antioxidants. Pregnancy is a period when women undergo a physiological state of oxidative stress due to hormonal changes and increased oxygen requirements to maintain pregnancy. However, when oxidative stress exceeds antioxidant capacity, this leads to cellular damage that promotes a diabetogenic state. Recent studies suggest a possible association between gestational diabetes and cognitive impairment, but the underlying mechanisms remain unclear.

Aims

We aim to explore the pathophysiological relationship between cognitive impairment and oxidative stress, focusing on the possible involvement of oxidative stress as the inducing mechanism.

Methods

We performed a comprehensive literature review through PubMed and Google Scholar. Our keywords were “neuroinflammation”, “cognitive impairment”, “gestational diabetes”, “oxidative stress”, “antioxidants”, and “free radicals”.

Results

From the initial 400 records identified, a total of 78 studies were analyzed and included in our study.

Conclusion

Oxidative stress plays a fundamental role in the development of cognitive impairment. Understanding this correlation is essential to the development of targeted medical interventions and, ultimately, promote research and prevention that will benefit the mother-child binomial in the short and long term.

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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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