内源性阿片类药物在肥胖症和饮食失调病理生理学中的作用。

Q3 Neuroscience Advances in neurobiology Pub Date : 2024-01-01 DOI:10.1007/978-3-031-45493-6_17

Sylvana Stephano Zuniga, Marcela Rodriguez Flores, Adriana Albu

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摘要

三部曲的第二章回顾并批判性地评估了内源性阿片系统（EOS）活动在肥胖和进食障碍的发生和发展过程中所起作用的科学证据。在此基础上，我们讨论了正常饮食和适应不良饮食行为的定义特征。我们回顾了有关肥胖和进食障碍的易感危险因素和病理生理学的科学文献。我们还回顾了针对肥胖、饮食紊乱和精神疾病之间关联的研究。最后，我们将讨论内源性阿片类物质在神经生物学和行为特征中的参与，以及 EOS 在肥胖和进食障碍中作用的临床证据。

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Role of Endogenous Opioids in the Pathophysiology of Obesity and Eating Disorders.

This second chapter in our trilogy reviews and critically appraises the scientific evidence for the role of endogenous opioid system (EOS) activity in the onset and progression of both obesity and eating disorders. Defining features of normative eating and maladaptive eating behaviors are discussed as a foundation. We review the scientific literature pertaining to the predisposing risk factors and pathophysiology for obesity and eating disorders. Research targeting the association between obesity, disordered eating, and psychiatric comorbidities is reviewed. We conclude by discussing the involvement of endogenous opioids in neurobiological and behavior traits, and the clinical evidence for the role of the EOS in obesity and eating disorders.

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