颗粒物和交通噪声诱发心血管损伤与经典风险因素高血压之间的病理机制协同作用。

IF 5.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants & redox signaling Pub Date : 2024-07-11 DOI:10.1089/ars.2024.0659
Marin Kuntic, Omar Hahad, Sadeer Al-Kindi, Matthias Oelze, Jos Lelieveld, Andreas Daiber, Thomas Münzel
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引用次数: 0

摘要

意义重大:在所有现代城市化和工业化社会中,心血管疾病(CVD)等非传染性疾病正日益成为发病和死亡的重要原因。高血压等传统的心血管疾病风险因素被吸烟和饮食等行为风险因素以及交通噪声和空气污染等环境风险因素所强化:最近的进展:在大样本人群中,交通噪音和空气污染都被证明会增加心血管疾病的风险。动物实验揭示了这些压力因素影响心血管系统的病理生理机制。噪音主要导致烦扰和睡眠障碍,促进应激激素的释放。空气污染主要损害肺部,导致局部炎症和氧化应激增加,并可扩散到血液循环和远处器官:噪音和空气污染都会在血管层面产生影响,炎症状态和氧化应激会导致血管信号传导功能失调,促进动脉粥样硬化斑块的形成和血栓形成。炎症和氧化应激都是动脉高血压等传统心血管风险因素的关键方面。环境危险因素诱发心血管疾病和高血压的机制具有相似性,这表明它们之间复杂的相互作用可推动心血管疾病的发生和发展,从而对健康产生协同影响:我们目前对噪声和空气污染对心血管系统负面影响的概述提供了与传统心血管疾病风险因素--高血压--的机理联系,可用于更好地保护原有心血管疾病患者。
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Pathomechanistic Synergy Between Particulate Matter and Traffic Noise-Induced Cardiovascular Damage and the Classical Risk Factor Hypertension.
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来源期刊
Antioxidants & redox signaling
Antioxidants & redox signaling 生物-内分泌学与代谢
CiteScore
14.10
自引率
1.50%
发文量
170
审稿时长
3-6 weeks
期刊介绍: Antioxidants & Redox Signaling (ARS) is the leading peer-reviewed journal dedicated to understanding the vital impact of oxygen and oxidation-reduction (redox) processes on human health and disease. The Journal explores key issues in genetic, pharmaceutical, and nutritional redox-based therapeutics. Cutting-edge research focuses on structural biology, stem cells, regenerative medicine, epigenetics, imaging, clinical outcomes, and preventive and therapeutic nutrition, among other areas. ARS has expanded to create two unique foci within one journal: ARS Discoveries and ARS Therapeutics. ARS Discoveries (24 issues) publishes the highest-caliber breakthroughs in basic and applied research. ARS Therapeutics (12 issues) is the first publication of its kind that will help enhance the entire field of redox biology by showcasing the potential of redox sciences to change health outcomes. ARS coverage includes: -ROS/RNS as messengers -Gaseous signal transducers -Hypoxia and tissue oxygenation -microRNA -Prokaryotic systems -Lessons from plant biology
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