KAP1/TRIM28--疱疹病毒生物学中的抗病毒和激病毒主角。

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Microbiology Pub Date : 2024-06-12 DOI:10.1016/j.tim.2024.05.007
Sumita Bhaduri-McIntosh, Beth A Rousseau
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引用次数: 0

摘要

组成型异染色质机制(HCM)沉默了人类基因组中的围中心染色质区域和内源性逆转录病毒元件,这种机制的失调会对衰老和癌症产生影响。通过招募表观遗传调节因子,Krüppel相关盒(KRAB)相关蛋白1(KAP1/TRIM28/TIF1β)对HCM的功能起着不可或缺的作用。KAP1 和 HCM 还能在表观遗传学上沉默传入疱疹病毒的 DNA 基因组,以加强潜伏性。除了基因沉默之外,最新的报告还强调了 KAP1 直接激活细胞基因转录的能力。在此,我们将讨论 KAP1 的方方面面,包括最近的研究结果,这些结果出人意料地将 KAP1 与炎症小体联系在一起,揭示了 KAP1 裂解是一种新的调控模式,并论证了 KAP1 的促疱疹病毒功能,该功能可确保疱疹病毒基因组从转录过渡到复制。
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KAP1/TRIM28 - antiviral and proviral protagonist of herpesvirus biology.

Dysregulation of the constitutive heterochromatin machinery (HCM) that silences pericentromeric regions and endogenous retroviral elements in the human genome has consequences for aging and cancer. By recruiting epigenetic regulators, Krüppel-associated box (KRAB)-associated protein 1 (KAP1/TRIM28/TIF1β) is integral to the function of the HCM. Epigenetically silencing DNA genomes of incoming herpesviruses to enforce latency, KAP1 and HCM also serve in an antiviral capacity. In addition to gene silencing, newer reports highlight KAP1's ability to directly activate cellular gene transcription. Here, we discuss the many facets of KAP1, including recent findings that unexpectedly connect KAP1 to the inflammasome, reveal KAP1 cleavage as a novel mode of regulation, and argue for a pro-herpesviral KAP1 function that ensures transition from transcription to replication of the herpesvirus genome.

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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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