地平线上的希望有望治愈脂肪肝的疗法

IF 19.3 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological Reviews Pub Date : 2024-07-01 DOI:10.1124/pharmrev.124.001269
Amirhossein Sahebkar, Ali H. Eid
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引用次数: 0

摘要

脂肪肝(SLD)是一种高发的慢性肝病,对全球健康构成重大挑战。脂肪肝的病理生理学涉及遗传、内分泌和代谢因素之间的相互作用。成功治疗 SLD 需要通过先进的成像技术和生物标志物等非侵入性方法进行准确诊断和疾病监测。目前,许多针对 SLD 的新兴药物疗法正在研发中,它们针对不同的途径,如胶原周转、纤维生成、炎症和新陈代谢。最近,用于治疗非肝硬化代谢功能障碍相关性脂肪性肝炎(MASH)的瑞美替罗(resmetirom)获得批准,这在满足对有效 SLD 治疗的未满足医疗需求方面具有里程碑意义。最后,应大力挖掘个性化医疗方法和跨学科合作在改善患者预后和减轻疾病负担方面的潜力。
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Hope on the Horizon: Promising Therapies for Steatotic Liver Disease
Steatotic liver disease (SLD) is a highly prevalent chronic liver disease with significant challenges for global health. The pathophysiology of SLD involves an interplay among genetic, endocrine, and metabolic factors. Successful management of SLD entails accurate diagnosis and disease monitoring through noninvasive methods such as advanced imaging techniques and biomarkers. Many emerging pharmacotherapies for SLD are now in the pipeline, which target different pathways like collagen turnover, fibrogenesis, inflammation, and metabolism. The recent approval of resmetirom for noncirrhotic metabolic dysfunction–associated steatohepatitis (MASH) has been a milestone in addressing the unmet medical need for an efficacious SLD treatment. Finally, the potential of personalized medicine approaches and interdisciplinary cooperation in improving patient outcomes and reducing disease burden should be strongly pursued.
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来源期刊
Pharmacological Reviews
Pharmacological Reviews 医学-药学
CiteScore
34.70
自引率
0.50%
发文量
40
期刊介绍: Pharmacological Reviews is a highly popular and well-received journal that has a long and rich history of success. It was first published in 1949 and is currently published bimonthly online by the American Society for Pharmacology and Experimental Therapeutics. The journal is indexed or abstracted by various databases, including Biological Abstracts, BIOSIS Previews Database, Biosciences Information Service, Current Contents/Life Sciences, EMBASE/Excerpta Medica, Index Medicus, Index to Scientific Reviews, Medical Documentation Service, Reference Update, Research Alerts, Science Citation Index, and SciSearch. Pharmacological Reviews offers comprehensive reviews of new pharmacological fields and is able to stay up-to-date with published content. Overall, it is highly regarded by scholars.
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