扩展植物病毒体:类伞状病毒利用宿主蛋白质移动

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI:10.1146/annurev-virology-111821-122718
Anne E Simon, Diego F Quito-Avila, Sayanta Bera
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引用次数: 0

摘要

在最近发现类伞形病毒(ULVs)之前,所有植物 RNA 病毒的标志性特征都是编码专门的 RNA 结合运动蛋白(MPs),通过门控质膜传递 RNA 基因组,建立系统感染。绝大多数超低病毒都具有类似伞状病毒的 RNA 依赖性 RNA 聚合酶和 3'- 末端结构,但它们的不同之处在于不编码细胞间和远距离 MP,也不依赖辅助病毒进行反包囊化和植物间传播。最近发现两类超低病毒不一定编码 MP,这拓展了我们对现代植物 RNA 病毒最低要求的认识。柑橘中的 ULV CY1 利用宿主蛋白 PHLOEM PROTEIN 2(PP2)进行系统运动,相关的 ULV 编码一种噬菌体蛋白,从而为许多 ULV 感染植物中缺乏辅助病毒提供了解释。因此,超低容量病毒与最早感染植物的病毒很相似,它们很可能是从进食生物体中沉积下来的,同样需要使用 PP2 等宿主蛋白才能从最初感染的细胞中排出。
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Expanding the Plant Virome: Umbra-Like Viruses Use Host Proteins for Movement.

Before the very recent discovery of umbra-like viruses (ULVs), the signature defining feature of all plant RNA viruses was the encoding of specialized RNA-binding movement proteins (MPs) for transiting their RNA genomes through gated plasmodesmata to establish systemic infections. The vast majority of ULVs share umbravirus-like RNA-dependent RNA polymerases and 3'-terminal structures, but they differ by not encoding cell-to-cell and long-distance MPs and by not relying on a helper virus for trans-encapsidation and plant-to-plant transmission. The recent finding that two groups of ULVs do not necessarily encode MPs is expanding our understanding of the minimum requirements for modern plant RNA viruses. ULV CY1 from citrus uses host protein PHLOEM PROTEIN 2 (PP2) for systemic movement, and related ULVs encode a capsid protein, thereby providing an explanation for the lack of helper viruses present in many ULV-infected plants. ULVs thus resemble the first viruses that infected plants, which were likely deposited from feeding organisms and would have similarly required the use of host proteins such as PP2 to exit initially infected cells.

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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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