唾液外泌体microRNA图谱作为头颈部鳞状细胞癌患者诊断和预后的生物监测工具:系统综述

IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Archives of oral biology Pub Date : 2024-05-27 DOI:10.1016/j.archoralbio.2024.106012
Lorenzo Sanesi , Giorgio Mori , Giuseppe Troiano , Andrea Ballini , Felice Valzano , Mario Dioguardi , Lorenzo Lo Muzio , Marco Magalhaes , Vito Carlo Alberto Caponio
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引用次数: 0

摘要

目的体外小泡是存在于唾液和其他体液中的细胞外小泡。这些囊泡的大小从 30 纳米到 150 纳米不等,在细胞间通信、运输不同的生物大分子、主动靶向细胞等方面发挥着重要作用。这些囊泡调节受体细胞内的生理和病理过程。微RNA(miRs)在外泌体中运输,并被输送到靶细胞,影响信号通路,在肿瘤发生过程中发挥重要的调控作用;例如,它们与头颈部鳞状细胞癌(HNSCC)等多种癌症的进展和浸润有关。材料与方法根据PRISMA指南,基于特定关键词在PubMed、Web of Science、Scopus和谷歌学术网上进行了系统的文献检索。本次综述只选择了原创文章。结果在筛选过程结束后,共纳入了 9 篇文章。在这些研究中,有 41 个 miRs 在健康受试者和 HNSCC 患者之间有差异表达。不同研究提取和分析外泌体 miRs 的技术各不相同。我们还介绍了唾液外泌体 miRs 的表达途径,以便深入了解病理机制。miR-10b-5p、miR-486-5p、miR-24-3p、miR-412-3p和miR-512-3p是最有希望用于诊断的标记物,而miR-1307-5p和miR-519c-3p则导致过表达,并与较差的生存结果相关。
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Salivary exosomal microRNA profile as biomonitoring tool for diagnosis and prognosis of patients with head and neck squamous cell carcinoma: a systematic review

Objective

Exosomes are extracellular vesicles found in saliva and other body fluids. These vesicles range in size from 30 to 150 nm and play a crucial role in intercellular communication, transporting different biomolecules, actively targeting cells. These vesicles regulate both physiological and pathological processes within recipient cells. MicroRNAs (miRs) are transported within exosomes and are delivered to target cells where they influence signaling pathways, taking on a crucial regulatory role in oncogenesis; for example, they are implicated in progression and infiltration of various cancers, such as head and neck squamous cell carcinoma (HNSCC).

Material and methods

A systematic literature search based on specific keywords, according to the PRISMA guidelines, was carried out on PubMed, Web of Science, Scopus, and Google Scholar. Only original articles were selected during this review. The risk of bias was assessed by QUADAS-2.

Results

At the end of the selection process 9 articles were included. In these studies, 41 miRs showed differential expression between healthy subjects and patient with HNSCC. The techniques varied among studies for the extraction and analysis of exosomal miRs. We presented also salivary exosomal miRs pathways, to give insights about pathogenetic mechanisms.

Conclusions

Exosomal microRNA are promising biomarkers for HNSCC detection. MiR-10b-5p, miR-486–5p, miR-24–3p, miR-412–3p, and miR-512–3p are the most promising markers applicable to diagnostics, while miR-1307–5p and miR-519c–3p resulted overexpressed and correlated to worse survival outcomes.

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来源期刊
Archives of oral biology
Archives of oral biology 医学-牙科与口腔外科
CiteScore
5.10
自引率
3.30%
发文量
177
审稿时长
26 days
期刊介绍: Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry
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