补充鼠李糖乳杆菌 HA-114 益生菌对超重人群限制热量饮食期间循环 IGFBP-2 水平的影响

IF 4.2 Q1 ENDOCRINOLOGY & METABOLISM Journal of Clinical and Translational Endocrinology Pub Date : 2024-06-01 DOI:10.1016/j.jcte.2024.100357
Justine Faramia , Béatrice S.-Y. Choi , Lucie Brunelle , André Marette , Vicky Drapeau , Angelo Tremblay , Frédéric Picard
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引用次数: 0

摘要

背景和目的肠道微生物群部分通过循环激素影响能量平衡。胰岛素样生长因子结合蛋白(IGFBP)-2 是一种生物标志物,其在全身循环中的增加与对体重和新陈代谢的积极影响有关。在最近的一项临床试验中,补充益生菌 Lacticaseibacillus rhamnosus HA-114 对接受减肥干预的超重参与者的饮食行为和胰岛素抵抗有积极影响。在这种情况下,本辅助研究旨在评估补充鼠李糖乳杆菌 HA-114 对这些人血浆 IGFBP-2 水平的影响,以及这种调节是否与脂肪量、能量代谢和饮食行为的变化相关。方法对 100 名参加为期 12 周的饮食减重计划(-500 千卡/天)的超重或肥胖男性和女性的空腹血浆 IGFBP-2 浓度进行量化,同时补充鼠李糖乳杆菌 HA-114 或安慰剂。循环 IGFBP-2 浓度的基线和变化与人体测量参数、葡萄糖和脂质代谢、心肺功能和饮食行为相关。IGFBP-2水平升高的人的体重指数下降幅度更大。在补充益生菌的组别中,IGFBP-2水平的变化与脂肪量的减少相关(r = 0.2,p < 0.001),但与其他代谢参数或饮食行为无关。结论 补充鼠李糖 HA-114 益生菌不会调节血浆 IGFBP-2 水平。IGFBP-2水平的变化与体重指数的降低有关,但与其他代谢参数或饮食行为无关,这表明HA-114对饮食行为的益处可能与IGFBP-2无关。要调节 IGFBP-2 并观察其与饮食行为和心血管代谢改善之间的关系,可能还需要微生物群的其他变化。
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Effects of Lacticaseibacillus rhamnosus HA-114 probiotic supplementation on circulating IGFBP-2 levels during a calorie-restricted diet in overweight humans

Background and aim

Gut microbiota influences energy homeostasis in part through circulating hormones. Insulin-like growth factor-binding protein (IGFBP)-2 is a biomarker whose increase in systemic circulation is associated with positive effects on body weight and metabolism. In a recent clinical trial, probiotic Lacticaseibacillus rhamnosus HA-114 supplementation showed positive effects on eating behaviors and insulin resistance in overweight participants undergoing a weight-loss intervention. In this context, this ancillary study aimed at assessing the impact of L. rhamnosus HA-114 supplementation on plasma IGFBP-2 levels in these individuals, and whether this modulation correlated with changes in fat mass, energy metabolism, and eating behaviors.

Methods

Fasting plasma IGFBP-2 concentrations were quantified in 100 overweight or obese men and women enrolled in a 12-week diet-based weight reduction program (−500 kcal/day), in combination with probiotic L. rhamnosus HA-114 or placebo supplementation. Baseline and changes in circulating IGFBP-2 concentrations were correlated with anthropometric parameter, glucose and lipid metabolism, cardiorespiratory function and eating behaviors.

Results

On average, the intervention reduced BMI by 4.6 % and increased IGFBP-2 by 13 %, regardless of supplementation group. Individuals who presented an increase in IGFBP-2 levels had significantly greater reductions in BMI. Changes in IGFBP-2 levels were correlated with loss in fat mass (r = 0.2, p < 0.001) in the probiotic-supplemented group, but not with other metabolic parameters or eating behaviors. Baseline IGFBP-2 levels were not associated with weight loss or improvements in cardiometabolic parameters.

Conclusion

Probiotic supplementation with L. rhamnosus HA-114 did not modulate plasma IGFBP-2 levels. Changes in IGFBP-2 levels were correlated with greater reductions in BMI, but not with other metabolic parameters or eating behaviors, indicating that the benefits of HA-114 on eating behaviors are likely independent of IGFBP-2. Additional changes in microbiota might be required to modulate IGFBP-2 and observe its associations with eating behaviors and cardiometabolic improvements.

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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
24
审稿时长
16 weeks
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