小面积缺血性卒中与大面积缺血性卒中心血管事件的发生率;一项为期三年的队列研究。

IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS ARYA Atherosclerosis Pub Date : 2023-09-01 DOI:10.48305/arya.2023.26660.2820
Marzieh Tajmirriahi, Mohammad Saadatnia, Hasan Shemirani, Masoumeh Sadeghi, Alireza Chamasemani, Ali Safaei
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引用次数: 0

摘要

导言:脑缺血和冠状动脉疾病(CAD)是导致全球死亡和发病的主要原因,两者在病理生理学上相互关联。脑缺血事件分为大血管疾病和小血管疾病。本研究比较了缺血性大血管疾病与小血管疾病脑缺血事件发生率的相关因素:本次队列研究对 2018-19 年期间大血管疾病(n=75)和小血管疾病(n=150)两组的 225 名缺血性脑卒中患者进行了研究。收集了患者的人口学、医学和临床特征。对他们进行了为期三年的CAD事件发生率随访,包括ST段抬高型心肌梗死(STEMI)、非ST段抬高型心肌梗死(NSTEMI)、不稳定型心绞痛(UA)和心脏性猝死(SCD)。收集了有关冠状动脉造影、计算机断层扫描(CTA)、单光子发射计算机断层扫描(SPECT)和治疗方法的数据:小血管与大血管 CVA 患者在 ACS 发生率(P-value=0.105)、事件类型(P-value=0.836)、血管造影(P-value=0.671)、SPECT(P-value=0.99)和 CTA 结果(P-value>0.99)以及接近 CAD(P-value=0.728)方面的差异均不显著。Cox回归评估显示,在对高血压、糖尿病、血脂异常、再中风和既往IHD病史进行调整后,大血管疾病与小血管疾病导致的CAD事件风险增加(HR=2.005,95%CI:1.093-2.988,P值=0.021):根据本研究的结果,缺血性脑卒中大血管受累与三年内缺血性心脏病发病概率增加两倍以上有关。
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The Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort Study.

Introduction: Cerebral ischemia and coronary artery disease (CAD), the major leading causes of mortality and morbidity worldwide, are pathophysiologically interrelated. Cerebral ischemic events are categorized as large or small vessels disease. The current study compares the factors related to CAD events incidence following ischemic large versus small disease CVA.

Method: The current cohort study was conducted on 225 patients with ischemic stroke in two groups of large (n=75) and small (n=150) vessel disease during 2018-19. The patients' demographic, medical, and clinical characteristics were recruited. They were followed for three years regarding the incidence of CAD events, including ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), unstable angina (UA), and sudden cardiac death (SCD). Data about the coronary angiography, computed tomography angiography (CTA), Single Photon Emission Computed Tomography (SPECT), and the therapeutic approach were gathered.

Results: There were insignificant differences between the patients with small versus large vessels CVA in terms of ACS incidence (P-value=0.105), type of the events (P-value=0.836), angiographic (P-value=0.671), SPECT (P-value=0.99) and CTA findings (P-value>0.99) and approached CAD (P-value=0.728). Cox regression assessments revealed an increased risk of CAD events due to large versus small vessels disease after adjustments for hypertension, diabetes mellitus, dyslipidemia, re-stroke, and the previous history of IHD (HR=2.005, 95%CI: 1.093-2.988, P-value=0.021).

Conclusion: According to the findings of this study, large-vessel involvement in an ischemic stroke was associated with more than a two-fold increase in the three-year probability of ischemic heart disease incidencet.

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来源期刊
ARYA Atherosclerosis
ARYA Atherosclerosis CARDIAC & CARDIOVASCULAR SYSTEMS-
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审稿时长
18 weeks
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