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The association between GJB2 gene (producing Cx26 protein) and the ventricular storm: A case report. GJB2 基因(产生 Cx26 蛋白)与心室风暴之间的关联:病例报告。
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-01 DOI: 10.48305/arya.2023.11842.0
Mohammad Hossein Nikoo, Mohammad Reza Hatamnejad, Zahra Emkanjoo, Alireza Arjangzadeh, Mehdi Motahari Moadab, Mehdi Bazrafshan, Hamed Bazrafshan Drissi

Background: A structural heart disease or functional electrical abnormalities can cause an electrical storm.

Case presentation: We present a young boy with an electrical storm who had no cardiac risk factors and a positive family history of sudden cardiac death. The stepwise diagnostic approach was ineffective in determining previously known causes as the origin of the electrical storm. However, whole-exome sequencing (with Next Generation Illumina Sequencing) revealed a mutation in the GJB2 (NM_004004:exon2:c.G71A:p.W24X) gene.

Conclusion: A mutation in the GJB2 gene, which forms the connexin 26 protein, a crucial component of the myocytes' intercalated disc of gap junction complex between the myocytes, results in an abnormal electrical cell-by-cell conductance, and, eventually, ventricular storm. General anesthesia was used to control the storm, and intracardiac pacing was fruitful in ceasing the subsequent VT storms.

背景:结构性心脏病或功能性电异常可导致电风暴:结构性心脏病或功能性电异常可导致电风暴:我们介绍了一名患有电击风暴的小男孩,他没有心脏风险因素,但有阳性心脏性猝死家族史。循序渐进的诊断方法无法确定电风暴的起因是之前已知的病因。然而,全外显子组测序(使用下一代 Illumina 测序技术)发现了 GJB2(NM_004004:exon2:c.G71A:p.W24X)基因突变:GJB2基因是构成肌细胞间隙连接复合物的肌细胞闰盘的重要组成部分,该基因突变会导致细胞间电传导异常,并最终导致心室风暴。医生采用全身麻醉控制了风暴,并通过心内起搏成功终止了随后的室颤风暴。
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引用次数: 0
Forty-seven years of Iranian cardiovascular disease scientific publication: A bibliometric and altmetric analysis. 伊朗心血管疾病科学出版物四十七年:文献计量学和 Altmetric 分析。
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-01 DOI: 10.48305/arya.2024.42080.2918
Ali Ouchi, Fezzeh Ebrahimi, Leila Nemati Anaraki, Seyed Abedin Hoseini Ahangari, Nasim Ansari

Background: The present study was conducted to investigate the scientific contributions of Iranians in the field of cardiovascular research, as indexed in the Scopus database, using bibliometric and altmetric methods.

Methods: This applied study was conducted with a scientometric approach, utilizing bibliometric and altmetric indicators. The research population consisted of the scientific works of Iranian researchers in the field of cardiovascular diseases, indexed in the Scopus database over a period of 47 years. For bibliometric analysis and the generation of co-citation, co-occurrence, and co-authorship maps, the authors employed VOS Viewer software and the bibliometrix package in the R programming language. In the final stage, articles mentioned on social media were analyzed and evaluated using an altmetric approach.

Results: The results indicated that the commencement point for the publication of documents was 1975, and there has been a steep increase in recent years. Moreover, the documents were primarily research articles out of 6853 retrieved documents, and a limited number of documents were single-authored. Other findings also revealed the co-authorship map of authors and the co-occurrence of words, highly cited authors and institutions, and highly frequent keywords, signifying the scientific collaboration of Iranian researchers with the United States and England. Altmetric analysis also demonstrated that 43.41% of documents were shared at least once on social media and had an Altmetric Attention score. Furthermore, the analysis of altmetric indices showed that Mendeley, Twitter, and News had the highest share of document mentions on social media, respectively.

Conclusion: The findings of the study can offer valuable information to researchers, managers, and policy makers to become aware of the current state of research in the field of cardiovascular diseases and implement the necessary policies to inform society and enhance public health status.

研究背景本研究采用文献计量学和高度计量学方法,调查 Scopus 数据库收录的伊朗人在心血管研究领域的科学贡献:这项应用研究采用科学计量学方法,利用文献计量学和计量经济学指标。研究对象包括 Scopus 数据库收录的伊朗研究人员 47 年来在心血管疾病领域的科学著作。作者使用 VOS Viewer 软件和 R 编程语言中的 bibliometrix 软件包进行文献计量分析并生成共引、共现和合著图。在最后阶段,使用altmetric方法对社交媒体上提及的文章进行了分析和评估:结果表明,1975 年是文献发表的起点,近年来文献数量急剧增加。此外,在检索到的 6853 篇文献中,以研究文章为主,单篇文献数量有限。其他研究结果还显示了作者的共同署名图谱和词的共同出现、高被引作者和机构以及高频关键词,这表明伊朗研究人员与美国和英国进行了科研合作。Altmetric 分析还表明,43.41% 的文件在社交媒体上至少被分享过一次,并有 Altmetric 关注度得分。此外,Altmetric 指数分析表明,Mendeley、Twitter 和 News 在社交媒体上的文档提及率分别最高:研究结果可为研究人员、管理人员和政策制定者提供有价值的信息,帮助他们了解心血管疾病领域的研究现状,并实施必要的政策,为社会提供信息,提高公众健康水平。
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引用次数: 0
The assessment of no-reflow phenomenon incidence in early versus delayed percutaneous coronary intervention following a primary fibrinolysis. 评估原发性纤维蛋白溶解术后早期经皮冠状动脉介入治疗与延迟经皮冠状动脉介入治疗的无回流现象发生率。
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-01 DOI: 10.48305/arya.2024.42104.2921
Afshin Amirpour, Mohammad Amin Behjati, Reihaneh Zavar, Ehsan Shirvani, Ehsan Zarepour, Razieh Hassannejad, Masoumeh Sadeghi, Raheleh Janghorbanian Poodeh, Ali Safaei, Shahin Sanaei, Nazanin Mahin Parvar

Background: Percutaneous coronary intervention (PCI) is the gold standard approach to ST-Segment Elevation Myocardial Infarction (STEMI). Fibrinolysis followed by PCI has been recommended. The current study aims to investigate the no-reflow phenomenon incidence in patients undergoing post-thrombolytic therapy PCI.

Methods: This cross-sectional study was conducted on 250 patients with STEMI who primarily received fibrinolytic therapy followed by early (3-24 hours) (n=231) or delayed (> 24 hours) (n=19) PCI. They were also subcategorized into four intervals: <6 hours (n=98), 6-12 hours (n=93), 12-24 hours (n=38), and ≥24 hours (n=21). The demographic and medical data of the patients were retrieved. The Thrombolysis in Myocardial Infarction score (TIMI) was assessed at baseline and at the end of PCI. A TIMI score other than 3 was defined as no-reflow.

Results: The incidence of the no-reflow phenomenon was not associated with any of the underlying demographic and medical characteristics of the patients (P-value>0.05). Despite the significantly higher rate of improvement in TIMI grading among those undergoing early PCI (P-value=0.04), as well as within less than 6 hours after thrombolytic therapy (P-value=0.031), the rate of the no-reflow phenomenon did not differ between the groups, neither by sorting them as early versus delayed (P-value=0.518) nor by categorizing them into four intervals (P-value=0.367).

Conclusion: Based on the findings of the current study, early PCI after fibrinolysis led to significantly improved TIMI flow. However, the incidence of no-reflow did not differ between the groups with early versus delayed post-fibrinolysis PCI.

背景:经皮冠状动脉介入治疗(PCI)是治疗 ST 段抬高型心肌梗死(STEMI)的金标准方法。建议先进行纤维蛋白溶解,然后再进行 PCI。本研究旨在调查接受溶栓治疗后 PCI 患者的无回流现象发生率:这项横断面研究的对象是 250 例 STEMI 患者,他们主要接受了纤维蛋白溶解治疗,然后进行了早期(3-24 小时)(231 例)或延迟(> 24 小时)(19 例)PCI。他们还被细分为四个区间:结果无血流回流现象的发生率与患者的基本人口学和医学特征无关(P 值>0.05)。尽管接受早期 PCI(P-value=0.04)以及溶栓治疗后不到 6 小时内(P-value=0.031)的患者的 TIMI 分级改善率明显更高,但无论是按早期还是延迟(P-value=0.518)分类,还是按四个区间(P-value=0.367)分类,各组间的无回流现象发生率均无差异:根据目前的研究结果,纤溶后早期PCI可显著改善TIMI血流。结论:根据本研究的结果,纤溶后早期PCI可明显改善TIMI血流,但纤溶后早期PCI组与纤溶后延迟PCI组的无血流发生率并无差异。
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引用次数: 0
Cardiomyopathy discovered during pregnancy: Insights from speckle tracking echocardiography in a cohort of pregnant patients. 孕期发现的心肌病:从一组妊娠患者的斑点追踪超声心动图中获得的启示。
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-01 DOI: 10.48305/arya.2024.42400.2932
Parvin Bahrami, Azam Soleimani, Reihaneh Zavar, Hosein Masoumi, Farzad Adelparvar

Background: Heart failure (HF) is considered the leading cause of cardiac-related morbidity and mortality during pregnancy. Peripartum cardiomyopathy (PPCM) presents diagnostic challenges, often mirroring dilated cardiomyopathy (DCM). The aim of the study is to evaluate echocardiographic features, including global and segmental longitudinal strain values, in pregnant women with a history of newly diagnosed left ventricular systolic dysfunction (LVSD) in the third trimester of pregnancy.

Methods: This cross-sectional study, conducted in two referral cardio-obstetric clinics in Isfahan, Iran, enrolled pregnant women with newly diagnosed LV systolic dysfunction in the third trimester of pregnancy. A multidisciplinary pregnancy heart team assessed the patients. Reevaluation of patients and advanced echocardiographic investigation, including speckle tracking echocardiography (STE), were performed at least six months after delivery.

Results: The study included 26 pregnant women. Baseline characteristics revealed varying NYHA functional classes and etiologies, including DCM or non-dilated LV cardiomyopathy and PPCM. Undiagnosed DCM with exacerbation during pregnancy or non-dilated LV cardiomyopathy were the most probable causes for LV systolic dysfunction (65.4%). In five cases, peripartum cardiomyopathy was more relevant. The mean global longitudinal strain (GLS) was -16.94% and -13.95% in PPCM and DCM, respectively. Significantly different regional longitudinal strain numbers among different LV segments in PPCM were observed (P=.042), whereas the segmental strain in DCM patients did not differ.

Conclusion: When LVSD is discovered late in pregnancy, it is not easy for the authors to differentiate between peripartum cardiomyopathy and other cardiomyopathies. Advanced echocardiographic techniques, particularly GLS analysis, may be valuable in differentiating between these conditions.

背景:心力衰竭(HF)被认为是妊娠期心脏相关疾病发病率和死亡率的主要原因。围产期心肌病(PPCM)给诊断带来了挑战,通常与扩张型心肌病(DCM)相似。本研究旨在评估妊娠三个月内新诊断出左心室收缩功能障碍(LVSD)的孕妇的超声心动图特征,包括整体和节段纵向应变值:这项横断面研究在伊朗伊斯法罕的两家心血管产科转诊诊所进行,招募了妊娠三个月新诊断出左心室收缩功能障碍的孕妇。一个多学科妊娠心脏小组对患者进行了评估。至少在产后六个月对患者进行重新评估和高级超声心动图检查,包括斑点追踪超声心动图(STE):研究共纳入 26 名孕妇。基线特征显示了不同的 NYHA 功能分级和病因,包括 DCM 或非扩张型左心室心肌病和 PPCM。未确诊的 DCM 在孕期加重或非扩张型左心室心肌病是导致左心室收缩功能障碍的最可能原因(65.4%)。在五个病例中,与围产期心肌病更为相关。PPCM 和 DCM 的平均整体纵向应变(GLS)分别为-16.94%和-13.95%。在PPCM患者中,不同左心室节段的区域纵向应变数有显著差异(P=.042),而在DCM患者中,节段应变没有差异:结论:当 LVSD 在妊娠晚期被发现时,作者不容易区分围产期心肌病和其他心肌病。先进的超声心动图技术,尤其是 GLS 分析,可能对区分这些疾病很有价值。
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引用次数: 0
Effects of balloon pulmonary valvuloplasty on longitudinal changes in right ventricular strain and strain rate in pediatric pulmonary stenosis. 球囊肺动脉瓣成形术对小儿肺动脉狭窄患者右心室应变和应变率纵向变化的影响。
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-01 DOI: 10.48305/arya.2023.41893.2906
Alireza Ahmadi, Mohammad Reza Sabri, Mehdi Ghaderian, Davood Ramezani Nezhad, Bahar Dehghan, Chehreh Mahdavi, Mohsen Sedighi

Background: Balloon Pulmonary Valvuloplasty (BPV) is a procedure for Pulmonary Stenosis (PS) treatment. In this study, right ventricle (RV) performance was determined through 2D-Speckle Tracking Echocardiography (2D-STE).

Methods: The study involved 25 diagnosed children with PS undergoing BPV and 25 normal children. They were examined using 2D-STE and Linear Mixed Model (LMM) approach was used to determine changes in Pulmonary Valve Peak Gradient (PVPG), Tricuspid Annular Plane Systolic Excursion (TAPSE), strain and Strain Rate (SR) for RV, and Ejection Fraction for Left Ventricle (LVEF).

Results: Notable differences were found between two groups in TAPSE (P=0.001), global strain (P=0.001), apical septal strain (P=0.024), middle septal strain (P=0.001), basal septal strain (P=0.001), apical lateral SR (P=0.001), middle lateral SR (P=0.007), basal lateral SR (P=0.001), and apical septal SR (P=0.001). Post-BPV, there was an increase in LVEF (P=0.001) and TAPSE (P=0.001) but PVPG decreased (P=0.001). Following BPV, an increase was observed in apical lateral strain (P=0.004), middle septal strain (P=0.001), apical septal strain (P=0.003), middle septal strain (P=0.001), basal septal strain (P=0.048), apical septal SR (P=0.025), and middle septal SR (P=0.023). Gender was remarkably correlated with mean changes in basal lateral strain (P=0.019), middle septal strain (P=0.037), and middle septal SR (P=0.020). Age of PS children was related to mean change in basal septal strain (P=0.031) and basal septal SR (P=0.018).

Conclusion: Strain and SR in RV improved post-BPV in children with PS. The gender and age of the children revealed remarkable effects on RV strain and SR changes after BPV.

背景:球囊肺动脉瓣成形术(BPV)是治疗肺动脉狭窄(PS)的一种方法。本研究通过二维斑点追踪超声心动图(2D-STE)确定右心室(RV)的性能:研究涉及 25 名确诊为 PS 并接受 BPV 治疗的儿童和 25 名正常儿童。研究使用二维啄木鸟跟踪超声心动图(2D-STE)和线性混合模型(LMM)方法对他们进行检查,以确定肺动脉瓣峰值阶差(PVPG)、三尖瓣环平面收缩期偏移(TAPSE)、左心室应变和应变率(SR)以及左心室射血分数(LVEF)的变化:两组在 TAPSE(P=0.001)、整体应变(P=0.001)、室间隔顶端应变(P=0.024)、室间隔中部应变(P=0.001)、室间隔基底应变(P=0.001)、室间隔顶端侧 SR(P=0.001)、室间隔中部侧 SR(P=0.007)、室间隔基底侧 SR(P=0.001)和室间隔顶端 SR(P=0.001)方面存在显著差异。BPV 后,LVEF(P=0.001)和 TAPSE(P=0.001)增加,但 PVPG 下降(P=0.001)。BPV 后,观察到心尖外侧应变(P=0.004)、室间隔中部应变(P=0.001)、心尖室间隔应变(P=0.003)、室间隔中部应变(P=0.001)、室间隔基底应变(P=0.048)、心尖室间隔 SR(P=0.025)和室间隔中部 SR(P=0.023)增加。性别与基底侧应变(P=0.019)、中隔应变(P=0.037)和中隔SR(P=0.020)的平均变化显著相关。PS患儿的年龄与基底室间隔应变(P=0.031)和基底室间隔SR(P=0.018)的平均变化有关:结论:PS患儿室间隔应变和SR在BPV术后有所改善。儿童的性别和年龄对 BPV 后 RV 应变和 SR 变化有显著影响。
{"title":"Effects of balloon pulmonary valvuloplasty on longitudinal changes in right ventricular strain and strain rate in pediatric pulmonary stenosis.","authors":"Alireza Ahmadi, Mohammad Reza Sabri, Mehdi Ghaderian, Davood Ramezani Nezhad, Bahar Dehghan, Chehreh Mahdavi, Mohsen Sedighi","doi":"10.48305/arya.2023.41893.2906","DOIUrl":"10.48305/arya.2023.41893.2906","url":null,"abstract":"<p><strong>Background: </strong>Balloon Pulmonary Valvuloplasty (BPV) is a procedure for Pulmonary Stenosis (PS) treatment. In this study, right ventricle (RV) performance was determined through 2D-Speckle Tracking Echocardiography (2D-STE).</p><p><strong>Methods: </strong>The study involved 25 diagnosed children with PS undergoing BPV and 25 normal children. They were examined using 2D-STE and Linear Mixed Model (LMM) approach was used to determine changes in Pulmonary Valve Peak Gradient (PVPG), Tricuspid Annular Plane Systolic Excursion (TAPSE), strain and Strain Rate (SR) for RV, and Ejection Fraction for Left Ventricle (LVEF).</p><p><strong>Results: </strong>Notable differences were found between two groups in TAPSE (<i>P=0.001</i>), global strain (<i>P=0.001</i>), apical septal strain (<i>P=0.024</i>), middle septal strain (<i>P=0.001</i>), basal septal strain (<i>P=0.001</i>), apical lateral SR (<i>P=0.001</i>), middle lateral SR (<i>P=0.007</i>), basal lateral SR (<i>P=0.001</i>), and apical septal SR (<i>P=0.001</i>). Post-BPV, there was an increase in LVEF (<i>P=0.001</i>) and TAPSE (<i>P=0.001</i>) but PVPG decreased (<i>P=0.001</i>). Following BPV, an increase was observed in apical lateral strain (<i>P=0.004</i>), middle septal strain (<i>P=0.001</i>), apical septal strain (<i>P=0.003</i>), middle septal strain (<i>P=0.001</i>), basal septal strain (<i>P=0.048</i>), apical septal SR (<i>P=0.025</i>), and middle septal SR (<i>P=0.023</i>). Gender was remarkably correlated with mean changes in basal lateral strain (<i>P=0.019</i>), middle septal strain (<i>P=0.037</i>), and middle septal SR (<i>P=0.020</i>). Age of PS children was related to mean change in basal septal strain (<i>P=0.031</i>) and basal septal SR (<i>P=0.018</i>).</p><p><strong>Conclusion: </strong>Strain and SR in RV improved post-BPV in children with PS. The gender and age of the children revealed remarkable effects on RV strain and SR changes after BPV.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 2","pages":"41-49"},"PeriodicalIF":0.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence of myocardial infarction in the elderly: A systematic review and meta-analysis. 老年人心肌梗死的发病率:系统回顾和荟萃分析。
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-01 DOI: 10.48305/arya.2024.42327.2930
Fatemeh Rajati, Mojgan Rajati, Maryam Chegeni, Mohsen Kazeminia

Background: Myocardial Infarction (MI) refers to the destruction and death of cells in the myocardium of the heart. Its prevalence increases with age due to changes in the cardiovascular system. The aim of the present study was to combine, summarize, standardize, resolve inconsistencies in the results of studies, and investigate the impact of potential factors on the prevalence rate of MI in the elderly through a systematic review and meta-analysis.

Methods: This systematic review and meta-analysis was conducted from 1987 to March 2022. All relevant published studies were searched in PubMed, Embase, Scopus, Web of Science (WoS) databases, and Google Scholar search engine using related MeSH/Emtree and Free Text words. The heterogeneity among studies was quantified using the I2 index.

Results: In the initial search, 35453 studies were identified. After eliminating irrelevant studies, finally, 29 articles with a sample size of 3279136 subjects were included in the meta-analysis. After combining the results of the studies included in the meta-analysis, the total prevalence of MI in the elderly was estimated to be 17.6% (95% CI: 12.8 - 23.7%), 16.1% (95% CI: 11.0 - 22.8%) in males, and 12.5% (95% CI: 9.2 - 16.8%) in females. The prevalence of MI increased with the year of publication and the mean age of the elderly (P < 0.001).

Conclusion: The results showed that due to the high prevalence of myocardial infarction (MI) in the elderly, it should be addressed within healthcare systems and policy makers should pay more attention to prevention of MI. However, considering the inclusion of heterogeneous studies, the pooled estimation should be interpreted with caution.

背景:心肌梗死(MI)是指心脏心肌细胞的破坏和死亡。由于心血管系统的变化,心肌梗死的发病率随着年龄的增长而增加。本研究的目的是通过系统回顾和荟萃分析,合并、总结、规范、解决研究结果中的不一致,并调查潜在因素对老年人心肌梗死患病率的影响:本系统回顾和荟萃分析的研究时间为 1987 年至 2022 年 3 月。使用相关的 MeSH/Emtree 和自由文本词在 PubMed、Embase、Scopus、Web of Science (WoS) 数据库和 Google Scholar 搜索引擎中检索所有已发表的相关研究。研究之间的异质性采用 I2 指数进行量化:结果:在最初的搜索中,共发现了 35453 项研究。剔除无关研究后,最终有 29 篇文章(样本量为 3279136 例受试者)被纳入荟萃分析。将纳入荟萃分析的研究结果合并后,估计心肌梗死在老年人中的总患病率为 17.6%(95% CI:12.8 - 23.7%),男性为 16.1%(95% CI:11.0 - 22.8%),女性为 12.5%(95% CI:9.2 - 16.8%)。心肌梗死的发病率随着发表年份和老年人平均年龄的增加而增加(P < 0.001):研究结果表明,由于心肌梗死(MI)在老年人中的高发病率,医疗保健系统应重视这一问题,政策制定者应更加关注心肌梗死的预防。然而,考虑到纳入的研究不尽相同,在解释汇总估算结果时应谨慎。
{"title":"The prevalence of myocardial infarction in the elderly: A systematic review and meta-analysis.","authors":"Fatemeh Rajati, Mojgan Rajati, Maryam Chegeni, Mohsen Kazeminia","doi":"10.48305/arya.2024.42327.2930","DOIUrl":"10.48305/arya.2024.42327.2930","url":null,"abstract":"<p><strong>Background: </strong>Myocardial Infarction (MI) refers to the destruction and death of cells in the myocardium of the heart. Its prevalence increases with age due to changes in the cardiovascular system. The aim of the present study was to combine, summarize, standardize, resolve inconsistencies in the results of studies, and investigate the impact of potential factors on the prevalence rate of MI in the elderly through a systematic review and meta-analysis.</p><p><strong>Methods: </strong>This systematic review and meta-analysis was conducted from 1987 to March 2022. All relevant published studies were searched in PubMed, Embase, Scopus, Web of Science (WoS) databases, and Google Scholar search engine using related MeSH/Emtree and Free Text words. The heterogeneity among studies was quantified using the I<sup>2</sup> index.</p><p><strong>Results: </strong>In the initial search, 35453 studies were identified. After eliminating irrelevant studies, finally, 29 articles with a sample size of 3279136 subjects were included in the meta-analysis. After combining the results of the studies included in the meta-analysis, the total prevalence of MI in the elderly was estimated to be 17.6% (95% CI: 12.8 - 23.7%), 16.1% (95% CI: 11.0 - 22.8%) in males, and 12.5% (95% CI: 9.2 - 16.8%) in females. The prevalence of MI increased with the year of publication and the mean age of the elderly (P < 0.001).</p><p><strong>Conclusion: </strong>The results showed that due to the high prevalence of myocardial infarction (MI) in the elderly, it should be addressed within healthcare systems and policy makers should pay more attention to prevention of MI. However, considering the inclusion of heterogeneous studies, the pooled estimation should be interpreted with caution.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 2","pages":"61-73"},"PeriodicalIF":0.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardioprotective effects of aerobic training in diabetic rats: Reducing cardiac apoptotic indices and oxidative stress for a healthier heart. 有氧训练对糖尿病大鼠心脏的保护作用:降低心脏凋亡指数和氧化应激,让心脏更健康
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-01 DOI: 10.48305/arya.2024.41976.2911
Mohammad Ali Gharaat, Hamid Reza Choobdari, Mohsen Sheykhlouvand

Background: The present study evaluated the effects of aerobic training with variable intensities on apoptotic indices of cardiac tissue in fatty diabetic rats.

Methods: Twenty-four male Wistar rats were randomly divided into non-diabetic (ND, n=8), trained diabetic (TD, n=8), and control diabetic (CD, n=8) groups. Following a high-fat dietary regimen, type 2 diabetes was induced by streptozotocin, with blood glucose levels above 300 mg/dL considered indicative of diabetes. The TD group underwent aerobic exercise five times a week for six weeks. Subsequently, measurements were taken for left ventricular end-diastolic (LVEDV) and end-systolic volumes (LVESV), ejection fraction (EF%), catalase, caspase-9, P53, glucose, insulin, and HOMA-IR.

Results: Aerobic training led to a significant decrease in blood glucose levels (P < 0.01), caspase-9 (P < 0.05), HOMA-IR (P < 0.05), and P53 expression (P < 0.001) compared with the CD group. LVEDV and LVESV decreased significantly (P < 0.05 for both), while LVEF increased significantly (P < 0.05). Catalase activation showed an insignificant increase in the TD group pre- to post-training compared to CD.

Conclusion: Incremental aerobic exercise training (6 weeks) may exert a cardioprotective effect in diabetic rats by reducing apoptosis and oxidative stress indices, while simultaneously increasing aerobic fitness and reducing body weight.

背景:本研究评估了不同强度的有氧训练对脂肪型糖尿病大鼠心脏组织凋亡指数的影响:24只雄性Wistar大鼠被随机分为非糖尿病组(ND,n=8)、训练糖尿病组(TD,n=8)和对照糖尿病组(CD,n=8)。按照高脂肪饮食方案,用链脲佐菌素诱发 2 型糖尿病,血糖水平超过 300 毫克/分升即为糖尿病。TD组每周进行五次有氧运动,持续六周。随后,测量左心室舒张末期容积(LVEDV)和收缩末期容积(LVESV)、射血分数(EF%)、过氧化氢酶、Caspase-9、P53、血糖、胰岛素和 HOMA-IR:结果:与 CD 组相比,有氧训练显著降低了血糖水平(P < 0.01)、caspase-9(P < 0.05)、HOMA-IR(P < 0.05)和 P53 表达(P < 0.001)。LVEDV 和 LVESV 显著下降(均 P < 0.05),而 LVEF 显著增加(P < 0.05)。与 CD 组相比,TD 组在训练前和训练后的过氧化氢酶活化增加不明显:结论:渐进式有氧运动训练(6 周)可通过减少细胞凋亡和氧化应激指数对糖尿病大鼠的心脏起到保护作用,同时还能提高有氧体能和减轻体重。
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引用次数: 0
Vitamin D deficiency and atrial fibrillation: A cross sectional single center study. 维生素 D 缺乏与心房颤动:一项横断面单中心研究。
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-01-01 DOI: 10.48305/arya.2024.42018.2915
Amir Askarinejad, Hooman Bakhshandeh, Mona Heidarali, Sara Adimi, Zahra Ghaemmaghami, Majid Haghjoo

Background: Atrial fibrillation (AF) augments the risk of stroke by 4-5 times. Vitamin D is pivotal in numerous metabolic pathways. A handful of studies have explored the correlation between vitamin D deficiency (VDD) and AF outcomes. Hence, the authors sought to assess the relationship between VDD and AF outcomes.

Methods: From December 2021 to February 2023, 190 patients with AF were incorporated into the authors' study. Given the seasonal fluctuation of vitamin D levels, these levels were examined from the start of December until the end of March.

Results: The final analysis comprised 190 patients (55.8% male) with an average age of 46.22±15.03. Vitamin D deficiency, insufficiency, and sufficiency were noted in 77 (40.5%), 46 (24.2%), and 67 (35.3%) patients, respectively. Fatigue and syncope were significantly more prevalent in the VDD group than in other groups. Three-vessel disease was more frequent in the VDD group (p-value=0.04). Mortality was more prevalent in patients with VDD (6.31%) compared to the VDI (2.10%) and VDS (0.05%) groups (p = 0.03). Successful cardioversion was significantly more prevalent in the VDS group (p = 0.03).

Conclusion: A sufficient level of vitamin D was linked with a better response to cardioversion. However, low vitamin D levels are correlated with higher mortality in AF patients.

背景:心房颤动会使中风风险增加 4-5 倍。维生素 D 在许多代谢途径中起着关键作用。只有少数研究探讨了维生素 D 缺乏症(VDD)与心房颤动结果之间的相关性。因此,作者试图评估维生素 D 缺乏与房颤结果之间的关系:从 2021 年 12 月到 2023 年 2 月,作者的研究共纳入了 190 名房颤患者。考虑到维生素 D 水平的季节性波动,从 12 月初到 3 月底对这些水平进行了检查:最终分析包括 190 名患者(55.8% 为男性),平均年龄(46.22±15.03)岁。维生素 D 缺乏、不足和充足的患者分别为 77 人(40.5%)、46 人(24.2%)和 67 人(35.3%)。维生素 D 缺乏组的疲劳和晕厥发生率明显高于其他组别。三血管疾病在 VDD 组更为常见(P 值=0.04)。与 VDI 组(2.10%)和 VDS 组(0.05%)相比,VDD 组患者的死亡率更高(6.31%)(p = 0.03)。VDS组成功心脏复律的比例明显更高(p = 0.03):结论:充足的维生素 D 水平与心脏复律的较佳反应有关。结论:充足的维生素 D 水平与心脏复律反应较好有关,但维生素 D 水平低与房颤患者死亡率较高有关。
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引用次数: 0
The impact of home care on individuals with chronic heart failure: A comprehensive review. 家庭护理对慢性心力衰竭患者的影响:一项全面的综述。
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-01-01 DOI: 10.48305/arya.2024.42356.2931
Faramarz Kalhor, Amir Shahzeydi, Mohsen Taghadosi

Background: Heart failure is a widespread condition linked to elevated mortality rates, readmission incidents, and healthcare expenditures. Home care has emerged as a promising strategy for managing patients with heart failure. This study seeks to comprehensively review the impact of home care on individuals diagnosed with heart failure.

Methods: A comprehensive review was conducted by searching for relevant articles in Persian and English using keywords such as 'Nursing,' 'Home care,' 'Home care services,' Health Care Costs,' 'Heart diseases,' and 'Heart failure' across various databases including SID, Magiran, Ovid, Scopus, Web of Science, CINAHL, ProQuest, Embase and Medline. The search was limited to articles published between 2000 and 2023, focusing on those suitable for the study's purpose.

Results: A total of 1,260 articles were initially identified. After eliminating duplicate and irrelevant articles, evaluating the availability of full texts, and applying entry and exit criteria, as well as utilizing the CONSORT, STROBE checklist, and JBI Checklist for qualitative assessment of the studies, a total of 13 English articles were deemed suitable for inclusion in the final review. These studies utilized various study designs to investigate the effects of home care on patients with heart failure.

Conclusion: The findings of this study suggest that home care has a positive impact on the quality of life, knowledge, and self-care of patients with heart failure. Additionally, it has been shown to reduce healthcare costs, readmission rates, and mortality. Therefore, it is recommended to prioritize home care for patients with chronic heart failure following discharge.

背景:心力衰竭是一种与高死亡率、再入院事件和医疗费用相关的普遍疾病。家庭护理已经成为治疗心力衰竭患者的一种很有前途的策略。本研究旨在全面回顾家庭护理对心力衰竭患者的影响。方法:在SID、Magiran、Ovid、Scopus、Web of Science、CINAHL、ProQuest、Embase和Medline等数据库中,使用“Nursing”、“Home care”、“Home care services”、“Health care Costs”、“Heart diseases”和“Heart failure”等关键词搜索波斯语和英语的相关文章,进行全面的综述。检索仅限于2000年至2023年之间发表的文章,重点关注那些适合研究目的的文章。结果:最初共鉴定了1260篇文章。在排除重复和不相关的文章,评估全文的可用性,应用入、出标准,以及使用CONSORT、STROBE检查表和JBI检查表对研究进行定性评估后,共有13篇英文文章被认为适合纳入最终审查。这些研究采用不同的研究设计来调查家庭护理对心力衰竭患者的影响。结论:本研究结果提示居家照护对心力衰竭患者的生活品质、知识及自我照护有正面影响。此外,它已被证明可以降低医疗保健费用、再入院率和死亡率。因此,建议慢性心力衰竭患者出院后优先考虑家庭护理。
{"title":"The impact of home care on individuals with chronic heart failure: A comprehensive review.","authors":"Faramarz Kalhor, Amir Shahzeydi, Mohsen Taghadosi","doi":"10.48305/arya.2024.42356.2931","DOIUrl":"10.48305/arya.2024.42356.2931","url":null,"abstract":"<p><strong>Background: </strong>Heart failure is a widespread condition linked to elevated mortality rates, readmission incidents, and healthcare expenditures. Home care has emerged as a promising strategy for managing patients with heart failure. This study seeks to comprehensively review the impact of home care on individuals diagnosed with heart failure.</p><p><strong>Methods: </strong>A comprehensive review was conducted by searching for relevant articles in Persian and English using keywords such as 'Nursing,' 'Home care,' 'Home care services,' Health Care Costs,' 'Heart diseases,' and 'Heart failure' across various databases including SID, Magiran, Ovid, Scopus, Web of Science, CINAHL, ProQuest, Embase and Medline. The search was limited to articles published between 2000 and 2023, focusing on those suitable for the study's purpose.</p><p><strong>Results: </strong>A total of 1,260 articles were initially identified. After eliminating duplicate and irrelevant articles, evaluating the availability of full texts, and applying entry and exit criteria, as well as utilizing the CONSORT, STROBE checklist, and JBI Checklist for qualitative assessment of the studies, a total of 13 English articles were deemed suitable for inclusion in the final review. These studies utilized various study designs to investigate the effects of home care on patients with heart failure.</p><p><strong>Conclusion: </strong>The findings of this study suggest that home care has a positive impact on the quality of life, knowledge, and self-care of patients with heart failure. Additionally, it has been shown to reduce healthcare costs, readmission rates, and mortality. Therefore, it is recommended to prioritize home care for patients with chronic heart failure following discharge.</p>","PeriodicalId":46477,"journal":{"name":"ARYA Atherosclerosis","volume":"20 3","pages":"45-56"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of traditional atherosclerotic risk factors in newly diagnosed colorectal and breast cancer patients. 新诊断的结直肠癌和乳腺癌患者中传统动脉粥样硬化危险因素的患病率
IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-01-01 DOI: 10.48305/arya.2024.41900.2908
Mohammad Rayati, Noushin Mohammadifard, Zamaneh Vafaei, Masood Shekarchizadeh, Samaneh Mostafavi, Reihaneh Zavar, Ali Darakhshandeh, Mehran Sharifi, Farzaneh Ashrafi, Mohammadreza Khosravifarsani, Ali Akhavan, Fariborz Mokarian, Nadia Najafizadeh, Alireza Sadeghi, Maryam Mirpourian, Jamshid Najafian, Nizal Sarrafzadegan

Due to the shared risk factors between cardiovascular disease (CVD) and certain cancers such as breast cancer (BC) and colorectal cancer (CRC), our study aimed to assess the CVD risk factors among newly diagnosed patients with BC and CRC. The study utilized baseline data from the ongoing Cardiovascular Events in Breast and Colorectal Cancers (CIBC) cohort study conducted in Isfahan since 2019. Only patients who had recently been diagnosed with BC or CRC and had not undergone any treatment were included in the study. Trained interviewers administered questionnaires to collect information on the demographic, socioeconomic, and smoking status of the participants. Additionally, metabolic and physical factors were measured following established guidelines. A total of 542 patients were included in the study, with 394 (72.7%) diagnosed with BC, 147 (27.1%) with CRC, and one patient having both conditions. The average age of BC patients was 49.46±11.15 years, which was younger compared to CRC patients. The majority of patients (90.8%) were nonsmokers, and a significant proportion (91.2%) did not engage in sufficient physical activity. Less than half of the patients exhibited hypertension, while the prevalence of diabetes was comparatively lower. Obesity, particularly abdominal obesity, was more common among BC patients compared to CRC patients. In our population, we observed that patients with CRC had a higher mean age compared to those with BC, and they exhibited a higher prevalence of common metabolic risk factors. On the other hand, obesity was more prevalent among BC patients. In terms of the shared risk factors between CVD and BC, our population experienced menarche within the expected timeframe, and the mean age of menopause was also within the normal range.

由于心血管疾病(CVD)与某些癌症(如乳腺癌(BC)和结直肠癌(CRC))具有共同的危险因素,我们的研究旨在评估新诊断的BC和CRC患者的CVD危险因素。该研究利用了自2019年以来在伊斯法罕进行的正在进行的乳腺癌和结直肠癌心血管事件(CIBC)队列研究的基线数据。只有最近被诊断为BC或CRC且未接受任何治疗的患者被纳入研究。训练有素的采访者通过问卷收集参与者的人口统计、社会经济和吸烟状况等信息。此外,根据既定的指导方针测量代谢和身体因素。该研究共纳入542例患者,其中394例(72.7%)诊断为BC, 147例(27.1%)诊断为CRC, 1例患者同时患有这两种疾病。BC患者的平均年龄为49.46±11.15岁,比CRC患者年轻。大多数患者(90.8%)不吸烟,有相当比例的患者(91.2%)没有进行足够的身体活动。不到一半的患者表现出高血压,而糖尿病的患病率相对较低。肥胖,尤其是腹部肥胖,在BC患者中比CRC患者更常见。在我们的人群中,我们观察到CRC患者的平均年龄高于BC患者,并且他们表现出更高的常见代谢危险因素的患病率。另一方面,肥胖在BC患者中更为普遍。就心血管疾病和BC之间的共同危险因素而言,我们的人群在预期的时间范围内经历了月经初潮,绝经的平均年龄也在正常范围内。
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引用次数: 0
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ARYA Atherosclerosis
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