{"title":"探索精氨酸介导的一氧化氮在预防健康疾病方面的药用意义","authors":"Mega Obukohwo Oyovwi , Adedeji David Atere","doi":"10.1016/j.ejmcr.2024.100175","DOIUrl":null,"url":null,"abstract":"<div><p><span>l</span>-Arginine is an essential amino acid that plays a crucial role in various physiological processes. It serves as a precursor for nitric oxide (NO), which has potent antioxidant and anti-inflammatory properties. This review aims to comprehensively examine the medicinal importance of <span>l</span>-arginine as a natural antioxidant in preventing human health disorders. A comprehensive literature search was conducted using PubMed, Google Scholar, and other databases. Studies investigating the antioxidant effects of <span>l</span>-arginine and its potential role in preventing various diseases were included. <span>l</span>-Arginine has been shown to mediate NO production with strong antioxidant properties, scavenging free radicals and reducing oxidative stress. It has demonstrated therapeutic potential in preventing and mitigating various health conditions, including: Cardiovascular diseases, Neurodegenerative diseases, Metabolic disorders, Immune function and Anti-aging effects. <span>l</span>-Arginine is a potent natural antioxidant with significant medicinal importance. Its ability to scavenge free radicals, improve endothelial function, and support immune function makes it a promising therapeutic agent for preventing and treating a wide range of human health disorders. Further research is warranted to fully elucidate the mechanisms of action and optimal dosage for specific conditions.</p></div>","PeriodicalId":12015,"journal":{"name":"European Journal of Medicinal Chemistry Reports","volume":"12 ","pages":"Article 100175"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772417424000475/pdfft?md5=c0b2d13d2ad9bff021457166d317b75f&pid=1-s2.0-S2772417424000475-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Exploring the medicinal significance of l-Arginine mediated nitric oxide in preventing health disorders\",\"authors\":\"Mega Obukohwo Oyovwi , Adedeji David Atere\",\"doi\":\"10.1016/j.ejmcr.2024.100175\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>l</span>-Arginine is an essential amino acid that plays a crucial role in various physiological processes. It serves as a precursor for nitric oxide (NO), which has potent antioxidant and anti-inflammatory properties. This review aims to comprehensively examine the medicinal importance of <span>l</span>-arginine as a natural antioxidant in preventing human health disorders. A comprehensive literature search was conducted using PubMed, Google Scholar, and other databases. Studies investigating the antioxidant effects of <span>l</span>-arginine and its potential role in preventing various diseases were included. <span>l</span>-Arginine has been shown to mediate NO production with strong antioxidant properties, scavenging free radicals and reducing oxidative stress. It has demonstrated therapeutic potential in preventing and mitigating various health conditions, including: Cardiovascular diseases, Neurodegenerative diseases, Metabolic disorders, Immune function and Anti-aging effects. <span>l</span>-Arginine is a potent natural antioxidant with significant medicinal importance. Its ability to scavenge free radicals, improve endothelial function, and support immune function makes it a promising therapeutic agent for preventing and treating a wide range of human health disorders. Further research is warranted to fully elucidate the mechanisms of action and optimal dosage for specific conditions.</p></div>\",\"PeriodicalId\":12015,\"journal\":{\"name\":\"European Journal of Medicinal Chemistry Reports\",\"volume\":\"12 \",\"pages\":\"Article 100175\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2772417424000475/pdfft?md5=c0b2d13d2ad9bff021457166d317b75f&pid=1-s2.0-S2772417424000475-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Medicinal Chemistry Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772417424000475\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Medicinal Chemistry Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772417424000475","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
l-Arginine 是一种必需氨基酸,在各种生理过程中发挥着至关重要的作用。它是一氧化氮(NO)的前体,而一氧化氮具有强大的抗氧化和抗炎特性。本综述旨在全面研究作为天然抗氧化剂的精氨酸在预防人类健康疾病方面的重要药用价值。我们使用 PubMed、Google Scholar 和其他数据库进行了全面的文献检索。研究表明,精氨酸能介导 NO 的产生,具有很强的抗氧化性,能清除自由基,减少氧化应激。它在预防和减轻各种健康状况方面具有治疗潜力,包括精氨酸是一种强效的天然抗氧化剂,具有重要的药用价值。它具有清除自由基、改善血管内皮功能和支持免疫功能的能力,使其成为预防和治疗多种人类健康疾病的一种有前途的治疗剂。要全面阐明其作用机制和针对特定病症的最佳剂量,还需要进一步的研究。
Exploring the medicinal significance of l-Arginine mediated nitric oxide in preventing health disorders
l-Arginine is an essential amino acid that plays a crucial role in various physiological processes. It serves as a precursor for nitric oxide (NO), which has potent antioxidant and anti-inflammatory properties. This review aims to comprehensively examine the medicinal importance of l-arginine as a natural antioxidant in preventing human health disorders. A comprehensive literature search was conducted using PubMed, Google Scholar, and other databases. Studies investigating the antioxidant effects of l-arginine and its potential role in preventing various diseases were included. l-Arginine has been shown to mediate NO production with strong antioxidant properties, scavenging free radicals and reducing oxidative stress. It has demonstrated therapeutic potential in preventing and mitigating various health conditions, including: Cardiovascular diseases, Neurodegenerative diseases, Metabolic disorders, Immune function and Anti-aging effects. l-Arginine is a potent natural antioxidant with significant medicinal importance. Its ability to scavenge free radicals, improve endothelial function, and support immune function makes it a promising therapeutic agent for preventing and treating a wide range of human health disorders. Further research is warranted to fully elucidate the mechanisms of action and optimal dosage for specific conditions.