Nan Chen, Chaokun Li, Shangteng Liao, Jinglong Chen, Xingxing Ma and Qiuling Song
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Brønsted acid-mediated selective α-alkenylation of 3,4-dihydro-2H-pyrans†
A protocol for the synthesis of α-alkenylated tetrahydropyrans (THPs) with 3,4-dihydro-2H-pyran derivatives and potassium alkenyltrifluoroborates was achieved in the presence of a Brønsted acid and a Lewis acid under mild reaction conditions. The oxonium ion intermediates, produced from various readily available 3,4-dihydro-2H-pyran derivatives, were attacked by the nucleophile to form the desired α-alkenylated products. This strategy could be an alternative approach to modify a series of modules that are of broad utility in natural products and fine chemicals.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.